▪ Abstract Src family protein tyrosine kinases are activated following engagement of many
different classes of cellular receptors and participate in signaling pathways that control a …

Prediction of chemical-induced hepatotoxicity in humans from in vitro data continues to be a
significant challenge for the pharmaceutical and chemical industries. Generally …

We identified hyaluronan synthase-2 (Has2) as a likely source of hyaluronan (HA) during
embryonic development, and we used gene targeting to study its function in vivo. Has2 …

Cell adhesion is critical for the genesis and maintenance of both three-dimensional structure
and normal function in tissues. The biochemical entities mediating cell adhesion are …

During embryonic development, certain tissues stream to their destinations by liquidlike
spreading movements. According to the 'differential adhesion hypothesis', these movements …

The neurofibromatosis-2 (NF2) gene encodes merlin, an ezrin-radixin-moesin-(ERM)-
related protein that functions as a tumor suppressor. We found that merlin mediates contact …

Integrins mediate cell adhesion, migration, and a variety of signal transduction events.
These integrin actions can overlap or even synergize with those of growth factors. We …

Background/aims: Several studies have reported that sodium hyaluronate is able to improve
both symptoms and signs in patients with dry eye but none have demonstrated an …

Integrin-associated signalling renders cells more resistant to genotoxic anti-cancer agents
like ionizing radiation and chemotherapeutic substances, a phenomenon termed cell …

The contribution of noncadherin-type, Ca2+-independent cell–cell adhesion molecules to
the organization of epithelial tissues is, as yet, unclear. A homophilic, epithelial Ca2+ …