Simple Summary For the research and development of drug discovery, it is of prime
importance to construct the three-dimensional (3D) tissue models in vitro. To this end, the …

The ability to reprogram the transcriptional circuitry by remodeling the three-dimensional
structure of the genome is exploited by cancer cells to promote tumorigenesis. This …

Protein-coding genes account for only~ 2% of the human genome, whereas the vast majority
of transcripts are non-coding RNAs (ncRNAs) including long ncRNAs (lncRNAs). A growing …

Neurodegenerative disorders are significantly increasing in incidence as the age of the
global population continues to climb with improved life expectancy. At present, more than 30 …

Glioblastoma multiforme (GBM) is the most common and lethal cancer of the adult brain,
remaining incurable with a median survival time of only 15 months. In an effort to identify …

Glioblastoma (GBM) is the most aggressive, deadliest, and most common brain malignancy
in adults. Despite the advances made in surgical techniques, radiotherapy and …

Cancer biomarkers with high selectivity, specificity and reproducibility play essential role in
diagnosis, prognosis and prediction of treatment efficacy in cancer patients. However, the …

Glioma is the most common malignant brain tumor that develops in the glial tissue. Several
studies have identified that glioma cancer stem cells (GCSCs) play important roles in tumor …

Recent studies have indicated that microRNAs (miRNAs) are important gene regulators that
play critical roles in biological processes and function as either tumour suppressors or …

Mounting evidence has indicated microRNA (miR) dysregulation and the Wnt/β-catenin
signaling pathway jointly drive carcinogenesis, cancer metastasis, and drug-resistance. The …