Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, with
several underlying pathophysiological mechanisms, some of which are still uncertain. The …

Dry eye can be caused by a variety of iatrogenic interventions. The increasing number of
patients looking for eye care or cosmetic procedures involving the eyes, together with a …

Corneal wound healing is a complex process involving cell death, migration, proliferation,
differentiation, and extracellular matrix remodeling. Many similarities are observed in the …

Diabetic corneal alterations, such as delayed epithelial wound healing, edema, recurrent
erosions, neuropathy/loss of sensitivity, and tear film changes are frequent but …

The corneal epithelial basement membrane (BM) is positioned between basal epithelial
cells and the stroma. This highly specialized extracellular matrix functions not only to anchor …

There is a number of systemic diseases affecting the cornea. These include endocrine
disorders (diabetes, Graves' disease, Addison's disease, hyperparathyroidism), infections …

Vascular basement membrane (BM) thickening has been hailed over half a century as the
most prominent histological lesion in diabetic microangiopathy, and represents an early …

Substance P (SP) is a neuropeptide, predominantly released from sensory nerve fibers, with
a potentially protective role in diabetic corneal epithelial wound healing. However, the …

A specialized microenvironment or niche, which regulates maintenance, self-renewal,
activation, and proliferation of stem cells by external signals, is one of the key prerequisites …

Significance: Laminins are complex extracellular macromolecules that are major players in
the control of a variety of core cell processes, including regulating rates of cell proliferation …