Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of
transposable elements (TE) such as retrotransposons. On a shorter time scale it has been …

Transposable elements give rise to interspersed repeats, sequences that comprise most of
our genomes. These mobile DNAs have been historically underappreciated—both because …

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Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

Mobile element insertions (MEIs) represent∼ 25% of all structural variants in human
genomes. Moreover, when they disrupt genes, MEIs can influence human traits and …

Although human LINE-1 (L1) elements are actively mobilized in many cancers, a role for
somatic L1 retrotransposition in tumor initiation has not been conclusively demonstrated …

Maintenance of phenotypic heterogeneity within cell populations is an evolutionarily
conserved mechanism that underlies population survival upon stressful exposures. We …

Improved biomarkers are needed for early cancer detection, risk stratification, treatment
selection, and monitoring treatment response. Although proteins can be useful blood-based …

Approximately 45% of the human genome is composed of transposable elements (TEs).
Expression of these elements is tightly regulated during normal development. TEs may be …

Cancer arises from a series of genetic and epigenetic changes, which result in abnormal
expression or mutational activation of oncogenes, as well as suppression/inactivation of …