The ability of the brain to store and process information relies on changing the strength of
connections between neurons. Synaptic facilitation is a form of short-term plasticity that …

MicroScale Thermophoresis (MST) is a powerful technique to quantify biomolecular
interactions. It is based on thermophoresis, the directed movement of molecules in a …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Microscale thermophoresis (MST) allows for quantitative analysis of protein interactions in
free solution and with low sample consumption. The technique is based on thermophoresis …

Exocytosis and endocytosis are essential physiological processes and are of prime
importance for brain function. Neurotransmission depends on the Ca 2+-triggered …

Hypertrophic cardiomyopathy (HCM) is primarily caused by mutations in β-cardiac myosin
and myosin-binding protein-C (MyBP-C). Changes in the contractile parameters of myosin …

Synaptic-vesicle exocytosis is mediated by the vesicular Ca2+ sensor synaptotagmin-1.
Synaptotagmin-1 interacts with the SNARE protein syntaxin-1A and acidic phospholipids …

C2 domains are membrane-binding modules that share a common overall fold: a single
compact Greek-key motif organized as an eight-stranded anti-parallel β-sandwich consisting …

Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

Parkinson's disease (PD) is characterized pathologically by the selective loss of substantia
nigra (SN) dopaminergic (DAergic) neurons. Recent evidence has suggested a role of …