P2Y12 inhibitor monotherapy in patients undergoing percutaneous coronary intervention
For 20 years, dual antiplatelet therapy (DAPT), consisting of the combination of aspirin and a
platelet P2Y12 receptor inhibitor, has been the gold standard of antithrombotic …
platelet P2Y12 receptor inhibitor, has been the gold standard of antithrombotic …
Sex differences in antiplatelet therapy: state-of-the art
A Gasecka, JM Zimodro, Y Appelman - Platelets, 2023 - Taylor & Francis
Antiplatelet therapy is a cornerstone of secondary prevention of cardiovascular diseases
(CVDs). However, current guidelines are based on data derived primarily from men, as …
(CVDs). However, current guidelines are based on data derived primarily from men, as …
Abbreviated or standard dual antiplatelet therapy by sex in patients at high bleeding risk: a prespecified secondary analysis of a randomized clinical trial
Importance Abbreviated dual antiplatelet therapy (DAPT) reduces bleeding with no increase
in ischemic events in patients at high bleeding risk (HBR) undergoing percutaneous …
in ischemic events in patients at high bleeding risk (HBR) undergoing percutaneous …
Sex differences in therapies against myocardial ischemia-reperfusion injury: from basic science to clinical perspectives
L Medzikovic, T Azem, W Sun, P Rejali, L Esdin… - Cells, 2023 - mdpi.com
Mortality from myocardial infarction (MI) has declined over recent decades, which could be
attributed in large part to improved treatment methods. Early reperfusion is the cornerstone …
attributed in large part to improved treatment methods. Early reperfusion is the cornerstone …
Advancing the access to cardiovascular diagnosis and treatment among women with cardiovascular disease: a joint British Cardiovascular Societies' consensus …
U Tayal, G Pompei, I Wilkinson, D Adamson, A Sinha… - Heart, 2024 - heart.bmj.com
Despite significant progress in cardiovascular pharmacotherapy and interventional
strategies, cardiovascular disease (CVD), in particular ischaemic heart disease, remains the …
strategies, cardiovascular disease (CVD), in particular ischaemic heart disease, remains the …
The Signaling Pathway of the ADP Receptor P2Y12 in the Immune System: Recent Discoveries and New Challenges
P2Y12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its
well-established role in platelet activation, blocking P2Y12 has been used as a therapeutic …
well-established role in platelet activation, blocking P2Y12 has been used as a therapeutic …
Sex-Based Outcomes of Dual-Antiplatelet Therapy After Percutaneous Coronary Intervention: A Pairwise and Network Meta-Analysis
Background Although dual antiplatelet therapy (DAPT) improves the outcomes of patients
undergoing percutaneous coronary intervention (PCI), sex-specific differences in efficacy …
undergoing percutaneous coronary intervention (PCI), sex-specific differences in efficacy …
Bleeding and ischemic risks of ticagrelor monotherapy after coronary interventions
Abstract Background In TWILIGHT (Ticagrelor With Aspirin or Alone in High-Risk Patients
After Coronary Intervention), among high-risk patients undergoing percutaneous coronary …
After Coronary Intervention), among high-risk patients undergoing percutaneous coronary …
Platelet P2Y12 signalling pathway in the dysregulated immune response during sepsis
Sepsis is a complicated pathological condition in response to severe infection. It is
characterized by a strong systemic inflammatory response, where multiple components of …
characterized by a strong systemic inflammatory response, where multiple components of …
[HTML][HTML] Secondary prevention of cardiovascular disease in women: closing the gap
A Thakkar, A Agarwala, ED Michos - European Cardiology Review, 2021 - ncbi.nlm.nih.gov
Cardiovascular disease (CVD) remains the leading cause of death in women globally.
Younger women (< 55 years of age) who experience MI are less likely to receive guideline …
Younger women (< 55 years of age) who experience MI are less likely to receive guideline …