Cytosolic Hsp90 isoform-specific functions and clinical significance
S Maiti, D Picard - Biomolecules, 2022 - mdpi.com
The heat shock protein 90 (Hsp90) is a molecular chaperone and a key regulator of
proteostasis under both physiological and stress conditions. In mammals, there are two …
proteostasis under both physiological and stress conditions. In mammals, there are two …
Probing organoid metabolism using fluorescence lifetime imaging microscopy (FLIM): The next frontier of drug discovery and disease understanding
Organoid models have been used to address important questions in developmental and
cancer biology, tissue repair, advanced modelling of disease and therapies, among other …
cancer biology, tissue repair, advanced modelling of disease and therapies, among other …
[HTML][HTML] Macromolecular condensation buffers intracellular water potential
Optimum protein function and biochemical activity critically depends on water availability
because solvent thermodynamics drive protein folding and macromolecular interactions …
because solvent thermodynamics drive protein folding and macromolecular interactions …
Effects of medications on heat loss capacity in chronic disease patients: health implications amidst global warming
Pharmacological agents used to treat or manage diseases can modify the level of heat strain
experienced by chronically ill and elderly patients via different mechanistic pathways …
experienced by chronically ill and elderly patients via different mechanistic pathways …
Lanthanide luminescence nanothermometer with working wavelength beyond 1500 nm for cerebrovascular temperature imaging in vivo
Nanothermometers enable the detection of temperature changes at the microscopic scale,
which is crucial for elucidating biological mechanisms and guiding treatment strategies …
which is crucial for elucidating biological mechanisms and guiding treatment strategies …
Bright and photostable TADF‐emitting zirconium (IV) pyridinedipyrrolide complexes: efficient dyes for decay time‐based temperature sensing and imaging
Luminescence thermometry represents a technique of choice for measurements in small
objects and imaging of temperature distribution. However, most state‐of‐the‐art luminescent …
objects and imaging of temperature distribution. However, most state‐of‐the‐art luminescent …
Artificial intelligence-based prediction of oral mucositis in patients with head-and-neck cancer: A prospective observational study utilizing a thermographic approach
Background: In patients with locally advanced head-and-neck squamous cell carcinoma
(HNSCC), chemoradiotherapy improves outcomes. Radiotherapy commonly causes …
(HNSCC), chemoradiotherapy improves outcomes. Radiotherapy commonly causes …
The influence of physiological and pathological perturbations on blood-brain barrier function
The blood-brain barrier (BBB) is located at the interface between the vascular system and
the brain parenchyma, and is responsible for communication with systemic circulation and …
the brain parenchyma, and is responsible for communication with systemic circulation and …
[HTML][HTML] Brain temperature in healthy and diseased conditions: A review on the special implications of MRS for monitoring brain temperature
Brain temperature determines not only an individual's cognitive functionality but also the
prognosis and mortality rates of many brain diseases. More specifically, brain temperature …
prognosis and mortality rates of many brain diseases. More specifically, brain temperature …
Circadian mechanisms in brain fluid biology
VS Vizcarra, RM Fame, LM Hablitz - Circulation Research, 2024 - Am Heart Assoc
The brain is a complex organ, fundamentally changing across the day to perform basic
functions like sleep, thought, and regulating whole-body physiology. This requires a …
functions like sleep, thought, and regulating whole-body physiology. This requires a …