Probing organoid metabolism using fluorescence lifetime imaging microscopy (FLIM): The next frontier of drug discovery and disease understanding
Organoid models have been used to address important questions in developmental and
cancer biology, tissue repair, advanced modelling of disease and therapies, among other …
cancer biology, tissue repair, advanced modelling of disease and therapies, among other …
[HTML][HTML] Cytosolic Hsp90 isoform-specific functions and clinical significance
S Maiti, D Picard - Biomolecules, 2022 - mdpi.com
The heat shock protein 90 (Hsp90) is a molecular chaperone and a key regulator of
proteostasis under both physiological and stress conditions. In mammals, there are two …
proteostasis under both physiological and stress conditions. In mammals, there are two …
Lanthanide luminescence nanothermometer with working wavelength beyond 1500 nm for cerebrovascular temperature imaging in vivo
Nanothermometers enable the detection of temperature changes at the microscopic scale,
which is crucial for elucidating biological mechanisms and guiding treatment strategies …
which is crucial for elucidating biological mechanisms and guiding treatment strategies …
[HTML][HTML] Macromolecular condensation buffers intracellular water potential
Optimum protein function and biochemical activity critically depends on water availability
because solvent thermodynamics drive protein folding and macromolecular interactions …
because solvent thermodynamics drive protein folding and macromolecular interactions …
Implication of thermal signaling in neuronal differentiation revealed by manipulation and measurement of intracellular temperature
S Chuma, K Kiyosue, T Akiyama, M Kinoshita… - Nature …, 2024 - nature.com
Neuronal differentiation—the development of neurons from neural stem cells—involves
neurite outgrowth and is a key process during the development and regeneration of neural …
neurite outgrowth and is a key process during the development and regeneration of neural …
[HTML][HTML] Effects of medications on heat loss capacity in chronic disease patients: health implications amidst global warming
Pharmacological agents used to treat or manage diseases can modify the level of heat strain
experienced by chronically ill and elderly patients via different mechanistic pathways …
experienced by chronically ill and elderly patients via different mechanistic pathways …
Stroke in the time of circadian medicine
P Mergenthaler, JS Balami, AA Neuhaus… - Circulation …, 2024 - ahajournals.org
Time-of-day significantly influences the severity and incidence of stroke. Evidence has
emerged not only for circadian governance over stroke risk factors, but also for important …
emerged not only for circadian governance over stroke risk factors, but also for important …
Circadian mechanisms in brain fluid biology
VS Vizcarra, RM Fame, LM Hablitz - Circulation Research, 2024 - ahajournals.org
The brain is a complex organ, fundamentally changing across the day to perform basic
functions like sleep, thought, and regulating whole-body physiology. This requires a …
functions like sleep, thought, and regulating whole-body physiology. This requires a …
Bright and photostable TADF‐emitting zirconium (IV) pyridinedipyrrolide complexes: efficient dyes for decay time‐based temperature sensing and imaging
Luminescence thermometry represents a technique of choice for measurements in small
objects and imaging of temperature distribution. However, most state‐of‐the‐art luminescent …
objects and imaging of temperature distribution. However, most state‐of‐the‐art luminescent …
[HTML][HTML] Elevated brain temperature under severe heat exposure impairs cortical motor activity and executive function
Background Excessive heat exposure can lead to hyperthermia in humans, which impairs
physical performance and disrupts cognitive function. While heat is a known physiological …
physical performance and disrupts cognitive function. While heat is a known physiological …