Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …

There are still great challenges for the effective treatment of infectious diseases, although
considerable achievement has been made by using antiviral and antimicrobial agents …

Multivalent interactions are omnipresent in biology and confer biological systems with
dramatically enhanced affinities towards different receptors. Such multivalent binding …

Abstract Treatment options for COVID-19 remain limited. Here, we report the optimization of
an siRNA targeting the highly conserved leader region of SARS-CoV-2. The siRNA was …

In addition to general unavailability of specific antiviral therapeutics for a variety of viral
diseases, usage of most antiviral drugs is linked to their limited solubility in aqueous media …

While significant progress has been made in understanding and applying gene silencing
mechanisms and the treatment of human diseases, there have been still several obstacles in …

Using nanostructured drug delivery systems has attracted increasing interest in
immunotherapeutic approaches. The intrinsic immunomodulatory properties and versatility …

Small interfering RNA (siRNA) is a promising drug candidate, expected to have broad
therapeutic potentials toward various diseases including viral infections and cancer. With …

Purpose Resistance to chemotherapeutic agents such as doxorubicin is a major reason for
cancer treatment failure. At present the treatment option for metastatic breast cancer is very …

Packaging multiple small interfering RNA (siRNA) molecules into nanostructures at precisely
defined ratios is a powerful delivery strategy for effective RNA interference (RNAi) therapy …