Oxidative and replication stress underlie genomic instability of cancer cells. Amplifying
genomic instability through radiotherapy and chemotherapy has been a powerful but …

Genomic instability is a key hallmark of cancer that arises owing to defects in the DNA
damage response (DDR) and/or increased replication stress. These alterations promote the …

A variety of targeted anticancer agents have been successfully introduced into clinical
practice, largely reflecting their ability to inhibit specific molecular alterations that are …

Fucoidan is a natural derived compound found in different species of brown algae and in
some animals, that has gained attention for its anticancer properties. However, the exact …

Endometrial cancer is the most commonly diagnosed gynecologic malignancy in the United
States. Endometrioid endometrial carcinomas constitute approximately 85% of newly …

Advanced and recurrent gynecological cancers are associated with poor prognosis and lack
of effective treatment. The developments of the molecular mechanisms on cancer …

PURPOSE The PAOLA-1/ENGOT-ov25 trial of maintenance olaparib plus bevacizumab for
newly diagnosed advanced high-grade ovarian cancer demonstrated a significant …

Endometrial cancer is the most prevalent gynecologic cancer in the United States. Over the
last 10 years, death rates from endometrial cancer have been rising about 1.4% per year …

Abstract The phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (AKT) signaling pathway
is involved in the regulation of multiple cellular physiological processes by activating …

More than half of cancer patients receive radiotherapy as a part of their cancer treatment.
DNA double-strand breaks (DSBs) are considered as the most lethal form of DNA damage …