It has been over 20 years since JUN amino-terminal kinases (JNKs) were identified as
protein kinases that are strongly activated by cellular stress and that have a key role in …

Members of the HECT family of E3 ubiquitin-protein ligases are characterized by a C-
terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate …

Exosomes are small extracellular 40–100 nm diameter membrane vesicles of late
endosomal origin that can mediate intercellular transfer of RNA s and proteins to assist …

ABSTRACT Homologous to E6AP C-terminus (HECT) E3 ubiquitin ligases play a critical role
in various cellular pathways, including but not limited to protein trafficking, subcellular …

O-linked N-acetylglucosamine (O-GlcNAc) is a reversible posttranslational modification of
Ser and Thr residues on cytosolic and nuclear proteins of higher eukaryotes catalyzed by O …

The brain changes in response to experience and altered environment. This neural plasticity
is largely mediated by morphological and functional modification of synapses, a process that …

A growing amount of evidence indicates that the neuronally expressed developmentally
downregulated 4 (NEDD4, also known as NEDD4-1) E3 ligase plays a critical role in a …

In the human brain, microRNAs (miRNAs) from the microRNA-376 (miR-376) cluster
undergo programmed “seed” sequence modifications by adenosine-to-inosine (A-to-I) …

The shape, structure and connectivity of nerve cells are important aspects of neuronal
function. Genetic and epigenetic factors that alter neuronal morphology or synaptic …

Ubiquitination plays a crucial role in regulating proteins post-translationally. The focus of this
review is on NEDD4, the founding member of the NEDD4 family of ubiquitin ligases that is …