Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

The plasma membrane of eukaryotic cells is not a simple sheet of lipids and proteins but is
differentiated into subdomains with crucial functions. Caveolae, small pits in the plasma …

A major challenge in understanding vertebrate embryogenesis is the lack of topographical
transcriptomic information that can help correlate microenvironmental cues within the …

Recent rapid progress in the field of mechanobiology has been driven by novel emerging
tools and methodologies and growing interest from different scientific disciplines. Specific …

Caveolae are abundant surface pits formed by the assembly of cytoplasmic proteins on a
platform generated by caveolin integral membrane proteins and membrane lipids. This …

In development, wound healing, and cancer metastasis, vertebrate cells move through 3D
interstitial matrix, responding to chemical and physical guidance cues. Protrusion at the cell …

Clathrin-independent endocytosis (CIE) mediates the cellular uptake of many extracellular
ligands, receptors, and pathogens, including several life-threatening bacterial toxins and …

Caveolae are 70–100 nm diameter plasma membrane invaginations found in abundance in
adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane …

Caveolae have been linked to many biological functions, but their precise roles are unclear.
Using quantitative whole-cell proteomics of genome-edited cells, we show that the oxidative …

Caveolae are one of the most abundant and striking features of the plasma membrane of
many mammalian cell types. These surface pits have fascinated biologists since their …