GTP-binding (G) proteins constitute a class of P-loop (phosphate-binding loop) proteins that
work as molecular switches between the GDP-bound OFF and the GTP-bound ON state. The …

Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

Voltage-gated calcium channels (CaVs) are large, transmembrane multiprotein complexes
that couple membrane depolarization to cellular calcium entry. These channels are central …

RGK proteins constitute a novel subfamily of small Ras-related proteins that function as
potent inhibitors of voltage-dependent (VDCC) Ca2+ channels and regulators of actin …

Ras-related associated with diabetes (RRAD), a member of the Ras-related GTPase
superfamily, is primarily a cytosolic protein that actives in the plasma membrane. RRAD is …

RGK proteins belong to the Ras superfamily of monomeric G-proteins, and currently include
four members—Rad, Rem, Rem2, and Gem/Kir. RGK proteins are broadly expressed, and …

RGK proteins (Kir/Gem, Rad, Rem, and Rem2) form a small subfamily of the Ras
superfamily. Despite a conserved GTP binding core domain, several differences suggest …

The RGK family of small G-proteins, including Rad, Gem, Rem1, and Rem2, is inducibly
expressed in various mammalian tissues and interacts with voltage-dependent calcium …

Background GEM (GTP-binding protein overexpressed in skeletal muscle) is one of the
atypical small GTPase subfamily members recently identified as a regulator of cell …

The Ras superfamily G-proteins are monomeric proteins of approximately 21 kDa that act as
a molecular switch to regulate a variety of cellular processes. The structure of the Ras …