Functional pathophysiology of SARS-CoV-2-induced acute lung injury and clinical implications

NM Habashi, L Camporota… - Journal of Applied …, 2021‏ - journals.physiology.org
The worldwide pandemic caused by the SARS-CoV-2 virus has resulted in over 84,407,000
cases, with over 1,800,000 deaths when this paper was submitted, with comorbidities such …

Mechanical ventilation in COVID‐19: A physiological perspective

JN Cronin, L Camporota, F Formenti - Experimental Physiology, 2022‏ - Wiley Online Library
New Findings What is the topic of this review? This review presents the fundamental
concepts of respiratory physiology and pathophysiology, with particular reference to lung …

Three broad classifications of acute respiratory failure etiologies based on regional ventilation and perfusion by electrical impedance tomography: a hypothesis …

H He, Y Chi, Y Long, S Yuan, R Zhang, Y Yang… - Annals of intensive …, 2021‏ - Springer
Background The aim of this study was to validate whether regional ventilation and perfusion
data measured by electrical impedance tomography (EIT) with saline bolus could …

[HTML][HTML] The cardiovascular effects of positive pressure ventilation

A Corp, C Thomas, M Adlam - BJA education, 2021‏ - Elsevier
Both left and right ventricular pressures are increased relative to atmospheric pressure
during positive pressure ventilation (PPV). Left ventricular transmural (or transaortic) …

Effects of impaired microvascular flow regulation on metabolism‐perfusion matching and organ function

TK Roy, TW Secomb - Microcirculation, 2021‏ - Wiley Online Library
Impaired tissue oxygen delivery is a major cause of organ damage and failure in critically ill
patients, which can occur even when systemic parameters, including cardiac output and …

[HTML][HTML] Experimental investigation of the effect of polymer matrices on polymer fibre optic oxygen sensors and their time response characteristics using a vacuum …

R Chen, F Formenti, H McPeak, AN Obeid… - Sensors and Actuators B …, 2016‏ - Elsevier
Very fast sensors that are able to track rapid changes in oxygen partial pressure (PO 2) in
the gas and liquid phases are increasingly required in scientific research–particularly in the …

Progress in the relationship between mechanical ventilation parameters and ventilator-related complications during perioperative anesthesia

H Yue, T Yong - Postgraduate medical journal, 2024‏ - academic.oup.com
Background Mechanical ventilation, as an important respiratory support, plays an important
role in general anesthesia and it is the cornerstone of intraoperative management of surgical …

[HTML][HTML] A fibre optic oxygen sensor that detects rapid PO2 changes under simulated conditions of cyclical atelectasis in vitro

F Formenti, R Chen, H McPeak, M Matejovic… - Respiratory physiology …, 2014‏ - Elsevier
Two challenges in the management of Acute Respiratory Distress Syndrome are the
difficulty in diagnosing cyclical atelectasis, and in individualising mechanical ventilation …

Real-time effects of PEEP and tidal volume on regional ventilation and perfusion in experimental lung injury

JB Borges, JN Cronin, DC Crockett… - Intensive care medicine …, 2020‏ - Springer
Background Real-time bedside information on regional ventilation and perfusion during
mechanical ventilation (MV) may help to elucidate the physiological and pathophysiological …

Intravascular oxygen sensors with novel applications for bedside respiratory monitoring

F Formenti, AD Farmery - Anaesthesia, 2017‏ - Wiley Online Library
Measurement allows us to quantify various parameters and variables in natural systems. In
addition, by measuring the effect by which a perturbation of one part of the system influences …