Cardiovascular disease is the leading cause of death in women and men globally, with most
due to atherosclerotic cardiovascular disease (ASCVD). Despite progress during the last 30 …

Hypertension is a frequent condition encountered during kidney disease development and a
leading cause in its progression. Hallmark factors contributing to hypertension constitute a …

The vascular endothelium is a dynamic, functionally complex organ, modulating multiple
biological processes, including vascular tone and permeability, inflammatory responses …

Arterial blood pressure is controlled by vasodilatory factors such as nitric oxide (NO) that are
released from the endothelium under the influence of fluid shear stress exerted by flowing …

Pathological vascular wall remodeling refers to the structural and functional changes of the
vessel wall that occur in response to injury that eventually leads to cardiovascular disease …

Vascular contributions to cognitive impairment and dementia (VCID) are characterized by
the aging neurovascular unit being confronted with and failing to cope with biological insults …

The consequences of cerebrovascular disease are among the leading health issues
worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the …

Atherosclerosis is a multifocal alteration of the vascular wall of medium and large arteries
characterized by a local accumulation of cholesterol and non-resolving inflammation …

Complex structural and functional changes occur in the arterial system with advancing age.
The aged artery is characterized by changes in micro RNA expression patterns, autophagy …

The cardiovascular system provides blood supply throughout the body and as such is
perpetually applying mechanical forces to cells and tissues. Thus, this system is primed with …