Advances in sequencing techniques and statistical methods have made it possible not only
to predict sequences of ancestral proteins but also to identify thousands of mutations in the …

Increasing our understanding of Earth's biodiversity and responsibly stewarding its
resources are among the most crucial scientific and social challenges of the new …

The genomes of placental mammals are being sequenced at an unprecedented rate.
Alignments of hundreds, and one day thousands, of genomes spanning the rich living and …

Colobines are a unique group of Old World monkeys that principally eat leaves and seeds
rather than fruits and insects. We report the sequencing at 146× coverage, de novo …

Background Multiple genes have been implicated by association studies in altering
inflammatory bowel disease (IBD) predisposition. Paediatric patients often manifest more …

The accelerating growth of data and knowledge in evolutionary biology is indisputable.
Despite this rapid progress, information remains scattered, poorly documented and in …

Increasing attention has been directed toward assessing mutational fallout of stereocilin
(STRC), the gene underlying DFNB16. A major challenge is due to a closely linked …

Protein structures are dynamic entities with a myriad of atomic fluctuations, side chain
rotations, and collective domain movements. While the importance of these dynamics to …

Many pathogenic missense mutations are found in protein positions that are neither well-
conserved nor fall in any known functional domains. Consequently, we lack any mechanistic …

Cancer development and progression result from somatic evolution by an accumulation of
genomic alterations. The effects of those alterations on the fitness of somatic cells lead to …