The neurobiology of stress: from serendipity to clinical relevance

BS McEwen - Brain research, 2000 - Elsevier
The hormones and other physiological agents that mediate the effects of stress on the body
have protective and adaptive effects in the short run and yet can accelerate pathophysiology …

Animal models of social stress: effects on behavior and brain neurochemical systems

RJ Blanchard, CR McKittrick, DC Blanchard - Physiology & behavior, 2001 - Elsevier
Social interactions serve as an evolutionarily important source of stress, and one that is
virtually ubiquitous among mammalian species. Animal models of social stress are varied …

Repeated restraint stress suppresses neurogenesis and induces biphasic PSA‐NCAM expression in the adult rat dentate gyrus

K Pham, J Nacher, PR Hof… - European Journal of …, 2003 - Wiley Online Library
Chronic restraint stress has been shown to induce structural remodelling throughout the
interconnected dentate gyrus‐CA3 fields. To find out how this stressor affects the rate of …

Effects of adverse experiences for brain structure and function

BS McEwen - Biological psychiatry, 2000 - Elsevier
Studies of the hippocampus as a target of stress and stress hormones have revealed a
considerable degree of structural plasticity in the adult brain. Repeated stress causes …

A critical review of chronic stress effects on spatial learning and memory

CD Conrad - Progress in neuro-psychopharmacology and biological …, 2010 - Elsevier
The purpose of this review is to evaluate the effects of chronic stress on hippocampal-
dependent function, based primarily upon studies using young, adult male rodents and …

Effects of chronic stress on hippocampal long‐term potentiation

C Pavlides, LG Nivón, BS McEwen - Hippocampus, 2002 - Wiley Online Library
Chronic stress causes atrophy of the apical dendrites of CA3 pyramidal neurons and deficits
in spatial memory. We investigated the effects of chronic stress on hippocampal physiology …

Experimental diabetes in rats causes hippocampal dendritic and synaptic reorganization and increased glucocorticoid reactivity to stress

AM Magariños, BS McEwen - Proceedings of the National Academy of …, 2000 - pnas.org
We report that 9 d of uncontrolled experimental diabetes induced by streptozotocin (STZ) in
rats is an endogenous chronic stressor that produces retraction and simplification of apical …

Stress, depression and hippocampal apoptosis

PJ Lucassen, VM Heine, MB Muller… - CNS & Neurological …, 2006 - ingentaconnect.com
In this review, we summarize and discuss recent studies on structural plasticity changes,
particularly apoptosis, in the mammalian hippocampus in relation to stress and depression …

The influence of stress hormones on emotional memory: relevance for psychopathology

OT Wolf - Acta psychologica, 2008 - Elsevier
Substantial progress within recent years has led to a better understanding of the impact of
stress on emotional memory. These effects are of relevance for understanding and treating …

[HTML][HTML] Actions of dehydroepiandrosterone and its sulfate in the central nervous system: effects on cognition and emotion in animals and humans

OT Wolf, C Kirschbaum - Brain Research Reviews, 1999 - Elsevier
Dehydroepiandrosterone (DHEA) and its sulfate ester, DHEAS, exert multiple effects in the
rodent central nervous system (CNS). Most of them seem to be mediated through their non …