Gene expression is regulated by genomic enhancers that recruit transcription factors and
cofactors to activate transcription from target core promoters. Over the past years, thousands …

Dosage compensation is an epigenetic mechanism that normalizes gene expression from
unequal copy numbers of sex chromosomes. Different organisms have evolved alternative …

Long noncoding RNAs (lncRNAs) are essential regulators of gene expression in eukaryotes.
Despite increasing knowledge on the function of lncRNAs, little is known about their effects …

Acetylation of lysine 16 on histone H4 (H4K16ac) is catalyzed by histone acetyltransferase
KAT8 and can prevent chromatin compaction in vitro. Although extensively studied in …

A functional crosstalk between epigenetic regulators and metabolic control could provide a
mechanism to adapt cellular responses to environmental cues. We report that the well …

The Drosophila piRNA pathway provides an RNA-based immune system that defends the
germline genome against selfish genetic elements. Two interrelated branches of the piRNA …

WDR5 is a highly conserved WD40 repeat-containing protein that is essential for proper
regulation of multiple cellular processes. WDR5 is best characterized as a core scaffolding …

Histone acetylation has been recognized as an important post‐translational modification of
core nucleosomal histones that changes access to the chromatin to allow gene transcription …

Compared with histone H3, acetylation of H4 tails has not been well studied, especially in
mammalian cells. Yet, H4K16 acetylation is of particular interest because of its ability to …

Summary The nucleoporin 98 gene (NUP98) is fused to a variety of partner genes in
multiple hematopoietic malignancies. Here, we demonstrate that NUP98 fusion proteins …