Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis

Y Li, J Wang, L Li, W Song, M Li, X Hua, Y Wang… - Natural product …, 2023 - pubs.rsc.org
Covering: up to 2022 Pentacyclic triterpenoids are important natural bioactive substances
that are widely present in plants and fungi. They have significant medicinal efficacy, play an …

A century of studying plant secondary metabolism—From “what?” to “where, how, and why?”

RA Dixon, AJ Dickinson - Plant Physiology, 2024 - academic.oup.com
Over the past century, early advances in understanding the identity of the chemicals that
collectively form a living plant have led scientists to deeper investigations exploring where …

Elucidation of the pathway for biosynthesis of saponin adjuvants from the soapbark tree

J Reed, A Orme, A El-Demerdash, C Owen, LBB Martin… - Science, 2023 - science.org
The Chilean soapbark tree (Quillaja saponaria) produces soap-like molecules called QS
saponins that are important vaccine adjuvants. These highly valuable compounds are …

Advances in biosynthesis, regulation, and metabolic engineering of plant specialized terpenoids

DA Nagegowda, P Gupta - Plant Science, 2020 - Elsevier
Plant specialized terpenoids are natural products that have no obvious role in growth and
development, but play many important functional roles to improve the plant's overall fitness …

Recent advances in triterpenoid pathway elucidation and engineering

S Dinday, S Ghosh - Biotechnology Advances, 2023 - Elsevier
Triterpenoids are among the most assorted class of specialized metabolites found in all the
taxa of living organisms. Triterpenoids are the leading active ingredients sourced from plant …

Characterization of the horse chestnut genome reveals the evolution of aescin and aesculin biosynthesis

W Sun, Q Yin, H Wan, R Gao, C **ong, C **e… - Nature …, 2023 - nature.com
Horse chestnut (Aesculus chinensis) is an important medicinal tree that contains various
bioactive compounds, such as aescin, barrigenol-type triterpenoid saponins (BAT), and …

Reshuffling of the ancestral core-eudicot genome shaped chromatin topology and epigenetic modification in Panax

ZH Wang, XF Wang, T Lu, MR Li, P Jiang… - Nature …, 2022 - nature.com
All extant core-eudicot plants share a common ancestral genome that has experienced
cyclic polyploidizations and (re) diploidizations. Reshuffling of the ancestral core-eudicot …

Using synthetic biology to understand the function of plant specialized metabolites

Y Bai, X Liu, IT Baldwin - Annual Review of Plant Biology, 2024 - annualreviews.org
Plant specialized metabolites (PSMs) are variably distributed across taxa, tissues, and
ecological contexts; this variability has inspired many theories about PSM function, which to …

Elucidation of the biosynthesis of asiaticoside and its reconstitution in yeast

X Zhao, W Wei, S Li, S Gao, S Liu… - ACS Sustainable …, 2024 - ACS Publications
Asiaticoside is a triterpenoid in Centella asiatica with wound healing and anti-inflammatory
activities. De novo production of asiaticoside remains incompletely resolved. To determine …

[HTML][HTML] A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules

J Reed, MJ Stephenson, K Miettinen, B Brouwer… - Metabolic …, 2017 - Elsevier
Plants are an excellent source of drug leads. However availability is limited by access to
source species, low abundance and recalcitrance to chemical synthesis. Although plant …