[HTML][HTML] Z-form extracellular DNA is a structural component of the bacterial biofilm matrix
Biofilms are community architectures adopted by bacteria inclusive of a self-formed
extracellular matrix that protects resident bacteria from diverse environmental stresses and …
extracellular matrix that protects resident bacteria from diverse environmental stresses and …
Contingency and chance erase necessity in the experimental evolution of ancestral proteins
The roles of chance, contingency, and necessity in evolution are unresolved because they
have never been assessed in a single system or on timescales relevant to historical …
have never been assessed in a single system or on timescales relevant to historical …
Probing Watson-Crick and Hoogsteen base pairing in duplex DNA using dynamic nuclear polarization solid-state NMR spectroscopy
The majority of base pairs in double-stranded DNA exist in the canonical Watson-Crick
geometry. However, they can also adopt alternate Hoogsteen conformations in various …
geometry. However, they can also adopt alternate Hoogsteen conformations in various …
Using quantum chemistry to estimate chemical shifts in biomolecules
DA Case - Biophysical chemistry, 2020 - Elsevier
An automated fragmentation quantum mechanics/molecular mechanics approach (AFNMR)
has shown promising results in chemical shift calculations for biomolecules. Sample results …
has shown promising results in chemical shift calculations for biomolecules. Sample results …
Hoogsteen base pairs increase the susceptibility of double-stranded DNA to cytotoxic damage
As the Watson–Crick faces of nucleobases are protected in dsDNA, it is commonly assumed
that deleterious alkylation damage to the Watson–Crick faces of nucleobases predominantly …
that deleterious alkylation damage to the Watson–Crick faces of nucleobases predominantly …
[HTML][HTML] Rapid assessment of Watson–Crick to Hoogsteen exchange in unlabeled DNA duplexes using high-power SELOPE imino H CEST
Abstract In duplex DNA, Watson–Crick A–T and G–C base pairs (bp's) exist in dynamic
equilibrium with an alternative Hoogsteen conformation, which is low in abundance and …
equilibrium with an alternative Hoogsteen conformation, which is low in abundance and …
Revealing AT and GC Hoogsteen base pairs in stressed protein-bound duplex DNA
Watson–Crick base pairs (bps) are the fundamental unit of genetic information and the
building blocks of the DNA double helix. However, AT and GC can also form alternative …
building blocks of the DNA double helix. However, AT and GC can also form alternative …
Infrared Spectroscopic Observation of a G–C+ Hoogsteen Base Pair in the DNA:TATA‐Box Binding Protein Complex Under Solution Conditions
Hoogsteen DNA base pairs (bps) are an alternative base pairing to canonical Watson–Crick
bps and are thought to play important biochemical roles. Hoogsteen bps have been reported …
bps and are thought to play important biochemical roles. Hoogsteen bps have been reported …
Molecular Insight into the Structural Dynamics of Holliday Junctions Modulated by Integration Host Factor
F Islam, PP Mishra - The Journal of Physical Chemistry B, 2024 - ACS Publications
The integration host factor (IHF) in Escherichia coli is a nucleoid-associated protein with
multifaceted roles that encompass DNA packaging, viral DNA integration, and …
multifaceted roles that encompass DNA packaging, viral DNA integration, and …
Binding of Homeodomain Proteins to DNA with Hoogsteen Base Pair
K Kole, J Chakrabarti - The Journal of Physical Chemistry B, 2025 - ACS Publications
In DNA double helices, Hoogsteen (HG) base pairing is an alternative mode of Watson–
Crick (WC) base pairing. HG bp has a different hydrogen bonding pattern than WC bp. We …
Crick (WC) base pairing. HG bp has a different hydrogen bonding pattern than WC bp. We …