The yeast Saccharomyces cerevisiae has been a favorite organism for pioneering studies
on nutrient-sensing and signaling mechanisms. Many specific nutrient responses have been …

Aberrant function of cell cycle regulators results in uncontrolled cell proliferation, making
them attractive therapeutic targets in cancer treatment. Indeed, survival of many cancers …

Stresses such as heat shock trigger the formation of protein aggregates and the induction of
a disaggregation system composed of molecular chaperones. Recent work reveals that …

Heat‐shock proteins (Hsps) and their cognates are primary mitigators of cell stress. With
increasingly severe impacts of climate change and other human modifications of the …

Cells must be able to cope with the challenge of folding newly synthesized proteins and
refolding those that have become misfolded in the context of a crowded cytosol. One such …

A mammalian cell houses two genomes located separately in the nucleus and mitochondria.
During evolution, communications and adaptations between these two genomes occur …

Diverse pathways drive resistance to BRAF/MEK inhibitors in BRAF-mutant melanoma,
suggesting that durable control of resistance will be a challenge. By combining statistical …

Abstract Heat Shock Proteins (HSPs) and their co-chaperones have well-established roles
in regulating proteostasis within the cell, the nature of which continues to emerge with further …

Heat shock protein (Hsp) 70 is a molecular chaperone that maintains protein homoeostasis
during cellular stress through two opposing mechanisms: protein refolding and degradation …

Hsp70 interactions are critical for cellular viability and the response to stress. Previous
attempts to characterize Hsp70 interactions have been limited by their transient nature and …