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Synovial inflammation in osteoarthritis progression
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …
Synovial inflammation is present in the OA joint and has been associated with radiographic …
Chemical design of activatable photoacoustic probes for precise biomedical applications
Y Liu, L Teng, B Yin, H Meng, X Yin, S Huan… - Chemical …, 2022 - ACS Publications
Photoacoustic (PA) imaging technology, a three-dimensional hybrid imaging modality that
integrates the advantage of optical and acoustic imaging, has great application prospects in …
integrates the advantage of optical and acoustic imaging, has great application prospects in …
Stem cell–homing hydrogel-based miR-29b-5p delivery promotes cartilage regeneration by suppressing senescence in an osteoarthritis rat model
J Zhu, S Yang, Y Qi, Z Gong, H Zhang, K Liang… - Science …, 2022 - science.org
Osteoarthritis (OA) is a common joint disease characterized by progressive loss of cartilage
and reduction in lubricating synovial fluid, which lacks effective treatments currently. Here …
and reduction in lubricating synovial fluid, which lacks effective treatments currently. Here …
Senescence in osteoarthritis: from mechanism to potential treatment
Y Liu, Z Zhang, T Li, H Xu, H Zhang - Arthritis Research & Therapy, 2022 - Springer
Osteoarthritis (OA) is an age-related cartilage degenerative disease, and chondrocyte
senescence has been extensively studied in recent years. Increased numbers of senescent …
senescence has been extensively studied in recent years. Increased numbers of senescent …
[HTML][HTML] Pathogenesis of osteoarthritis: risk factors, regulatory pathways in chondrocytes, and experimental models
As the most common chronic degenerative joint disease, osteoarthritis (OA) is the leading
cause of pain and physical disability, affecting millions of people worldwide. Mainly …
cause of pain and physical disability, affecting millions of people worldwide. Mainly …
Recent advances in the treatment of osteoarthritis
S Grässel, D Muschter - F1000Research, 2020 - pmc.ncbi.nlm.nih.gov
Osteoarthritis (OA) is one of the most debilitating diseases and is associated with a high
personal and socioeconomic burden. So far, there is no therapy available that effectively …
personal and socioeconomic burden. So far, there is no therapy available that effectively …
Role of inflammation and the immune system in the progression of osteoarthritis
JE Woodell‐May… - Journal of Orthopaedic …, 2020 - Wiley Online Library
Understanding the molecular drivers and feedback loops of osteoarthritis (OA) may provide
future therapeutic strategies to modulate the disease progression. The current paradigm of …
future therapeutic strategies to modulate the disease progression. The current paradigm of …
Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis
We elucidated the molecular cross-talk between cartilage and synovium in osteoarthritis, the
most widespread arthritis in the world, using the powerful tool of single-cell RNA …
most widespread arthritis in the world, using the powerful tool of single-cell RNA …
Osteoarthritis: toward a comprehensive understanding of pathological mechanism
Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …
Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
WH Robinson, CM Lepus, Q Wang, H Raghu… - Nature Reviews …, 2016 - nature.com
Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …