Synovial inflammation in osteoarthritis progression

E Sanchez-Lopez, R Coras, A Torres… - Nature Reviews …, 2022 - nature.com
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

Chemical design of activatable photoacoustic probes for precise biomedical applications

Y Liu, L Teng, B Yin, H Meng, X Yin, S Huan… - Chemical …, 2022 - ACS Publications
Photoacoustic (PA) imaging technology, a three-dimensional hybrid imaging modality that
integrates the advantage of optical and acoustic imaging, has great application prospects in …

Stem cell–homing hydrogel-based miR-29b-5p delivery promotes cartilage regeneration by suppressing senescence in an osteoarthritis rat model

J Zhu, S Yang, Y Qi, Z Gong, H Zhang, K Liang… - Science …, 2022 - science.org
Osteoarthritis (OA) is a common joint disease characterized by progressive loss of cartilage
and reduction in lubricating synovial fluid, which lacks effective treatments currently. Here …

Senescence in osteoarthritis: from mechanism to potential treatment

Y Liu, Z Zhang, T Li, H Xu, H Zhang - Arthritis Research & Therapy, 2022 - Springer
Osteoarthritis (OA) is an age-related cartilage degenerative disease, and chondrocyte
senescence has been extensively studied in recent years. Increased numbers of senescent …

[HTML][HTML] Pathogenesis of osteoarthritis: risk factors, regulatory pathways in chondrocytes, and experimental models

Y He, Z Li, PG Alexander, BD Ocasio-Nieves, L Yocum… - Biology, 2020 - mdpi.com
As the most common chronic degenerative joint disease, osteoarthritis (OA) is the leading
cause of pain and physical disability, affecting millions of people worldwide. Mainly …

Recent advances in the treatment of osteoarthritis

S Grässel, D Muschter - F1000Research, 2020 - pmc.ncbi.nlm.nih.gov
Osteoarthritis (OA) is one of the most debilitating diseases and is associated with a high
personal and socioeconomic burden. So far, there is no therapy available that effectively …

Role of inflammation and the immune system in the progression of osteoarthritis

JE Woodell‐May… - Journal of Orthopaedic …, 2020 - Wiley Online Library
Understanding the molecular drivers and feedback loops of osteoarthritis (OA) may provide
future therapeutic strategies to modulate the disease progression. The current paradigm of …

Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis

CH Chou, V Jain, J Gibson, DE Attarian… - Scientific Reports, 2020 - nature.com
We elucidated the molecular cross-talk between cartilage and synovium in osteoarthritis, the
most widespread arthritis in the world, using the powerful tool of single-cell RNA …

Osteoarthritis: toward a comprehensive understanding of pathological mechanism

DI Chen, J Shen, W Zhao, T Wang, L Han, JL Hamilton… - Bone research, 2017 - nature.com
Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

WH Robinson, CM Lepus, Q Wang, H Raghu… - Nature Reviews …, 2016 - nature.com
Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …