The immunological basis of liver allograft rejection

V Ronca, G Wootton, C Milani, O Cain - Frontiers in immunology, 2020 - frontiersin.org
Liver allograft rejection remains a significant cause of morbidity and graft failure in liver
transplant recipients. Rejection is caused by the recognition of non-self donor alloantigens …

A systematic review and meta‐analyses of regional perfusion in donation after circulatory death solid organ transplantation

J De Beule, K Vandendriessche… - Transplant …, 2021 - Wiley Online Library
In donation after circulatory death (DCD),(thoraco) abdominal regional perfusion (RP)
restores circulation to a region of the body following death declaration. We systematically …

Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant: the OCS liver PROTECT randomized clinical trial

JF Markmann, MS Abouljoud, RM Ghobrial… - JAMA …, 2022 - jamanetwork.com
Importance Ischemic cold storage (ICS) of livers for transplant is associated with serious
posttransplant complications and underuse of liver allografts. Objective To determine …

Transplantation of a human liver following 3 days of ex situ normothermic preservation

PA Clavien, P Dutkowski, M Mueller… - Nature …, 2022 - nature.com
Current organ preservation methods provide a narrow window (usually< 12 hours) to
assess, transport and implant donor grafts for human transplantation. Here we report the …

Liver transplantation for non-resectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelines

GK Bonney, CA Chew, P Lodge, J Hubbard… - The lancet …, 2021 - thelancet.com
Colorectal cancer is a prevalent disease worldwide, with more than 50% of patients
develo** metastases to the liver. Despite advances in improving resectability, most …

[HTML][HTML] Abdominal normothermic regional perfusion in controlled donation after circulatory determination of death liver transplantation: outcomes and risk factors for …

AJ Hessheimer, G de la Rosa, M Gastaca… - American Journal of …, 2022 - Elsevier
Postmortem normothermic regional perfusion (NRP) is a rising preservation strategy in
controlled donation after circulatory determination of death (cDCD). Herein, we present …

Liver transplantation outcomes from controlled circulatory death donors: SCS vs in situ NRP vs ex situ NMP

R Gaurav, AJ Butler, V Kosmoliaptsis… - Annals of …, 2022 - journals.lww.com
Objective: To compare the outcomes of livers donated after circulatory death (DCD) and
undergoing either in situ normothermic regional perfusion (NRP) or ex situ normothermic …

Expanding controlled donation after the circulatory determination of death: statement from an international collaborative

B Domínguez-Gil, N Ascher, AM Capron… - Intensive care …, 2021 - Springer
A decision to withdraw life-sustaining treatment (WLST) is derived by a conclusion that
further treatment will not enable a patient to survive or will not produce a functional outcome …

Immune cell dynamics deconvoluted by single-cell RNA sequencing in normothermic machine perfusion of the liver

T Hautz, S Salcher, M Fodor, G Sturm, S Ebner… - Nature …, 2023 - nature.com
Normothermic machine perfusion (NMP) has emerged as an innovative organ preservation
technique. Develo** an understanding for the donor organ immune cell composition and …

Sequential hypothermic and normothermic machine perfusion enables safe transplantation of high‐risk donor livers

OB van Leeuwen, SB Bodewes… - American Journal of …, 2022 - Wiley Online Library
Ex situ normothermic machine perfusion (NMP) is increasingly used for viability assessment
of high‐risk donor livers, whereas dual hypothermic oxygenated machine perfusion …