The extracellular matrix (ECM) is the complex meshwork of proteins and glycans that forms
the scaffold that surrounds and supports cells. It exerts key roles in all aspects of metazoan …

Glycoproteomics, or characterizing glycosylation events at a proteome scale, has seen rapid
advances in methods for analyzing glycopeptides by tandem mass spectrometry in recent …

Mass spectrometry is unmatched in its versatility for studying practically any aspect of the
proteome. Because the foundations of mass spectrometry-based proteomics are complex …

Proteins and lipids decorated with glycans are found throughout biological entities, playing
roles in biological functions and dysfunctions. Current analytical strategies for these glycan …

The FragPipe computational proteomics platform is gaining widespread popularity among
the proteomics research community because of its fast processing speed and user-friendly …

Here we present GlycanFinder, a database search and de novo sequencing tool for the
analysis of intact glycopeptides from mass spectrometry data. GlycanFinder integrates …

Cell surface glycosylation has a variety of functions, and its dysregulation in cancer
contributes to impaired signaling, metastasis and the evasion of the immune responses …

N-Glycoproteomics, the system-wide study of glycans asparagine-linked to protein carriers,
holds a unique and still largely untapped potential to provide deep insights into the …

Mucin-domain glycoproteins are densely O-glycosylated and play critical roles in a host of
biological functions. In particular, the T cell immunoglobulin and mucin-domain containing …

Despite ground-breaking innovations in experimental structural biology and protein structure
prediction techniques, capturing the structure of the glycans that functionalize proteins …