Drug resistance in epilepsy: clinical impact, potential mechanisms, and new innovative treatment options
Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide.
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …
The pharmacoresistant epilepsy: an overview on existant and new emerging therapies
A Fattorusso, S Matricardi, E Mencaroni… - Frontiers in …, 2021 - frontiersin.org
Epilepsy is one of the most common neurological chronic disorders, with an estimated
prevalence of 0. 5–1%. Currently, treatment options for epilepsy are predominantly based on …
prevalence of 0. 5–1%. Currently, treatment options for epilepsy are predominantly based on …
Incidence and prevalence of drug-resistant epilepsy: a systematic review and meta-analysis
B Sultana, MA Panzini, A Veilleux Carpentier… - Neurology, 2021 - AAN Enterprises
Objective To evaluate the incidence and prevalence of drug-resistant epilepsy (DRE) as well
as its predictors and correlates, we conducted a systematic review and meta-analysis of …
as its predictors and correlates, we conducted a systematic review and meta-analysis of …
Treatment outcomes in patients with newly diagnosed epilepsy treated with established and new antiepileptic drugs: a 30-year longitudinal cohort study
Importance A study published in 2000 showed that more than one-third of adults with
epilepsy have inadequate control of seizures with antiepileptic drugs (AEDs). This study …
epilepsy have inadequate control of seizures with antiepileptic drugs (AEDs). This study …
Epilepsy in older people
Globally, as populations age there will be challenges and opportunities to deliver optimal
health care to senior citizens. Epilepsy, a condition characterised by spontaneous recurrent …
health care to senior citizens. Epilepsy, a condition characterised by spontaneous recurrent …
Promises and limitations of human intracranial electroencephalography
Intracranial electroencephalography (iEEG), also known as electrocorticography when using
subdural grid electrodes or stereotactic EEG when using depth electrodes, is blossoming in …
subdural grid electrodes or stereotactic EEG when using depth electrodes, is blossoming in …
Seizure prediction—ready for a new era
Epilepsy is a common disorder characterized by recurrent seizures. An overwhelming
majority of people with epilepsy regard the unpredictability of seizures as a major issue …
majority of people with epilepsy regard the unpredictability of seizures as a major issue …
[HTML][HTML] Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind …
Background Everolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been used
for various benign tumours associated with tuberous sclerosis complex. We assessed the …
for various benign tumours associated with tuberous sclerosis complex. We assessed the …
Long-term brain network reorganization predicts responsive neurostimulation outcomes for focal epilepsy
Responsive neurostimulation (RNS) devices, able to detect imminent seizures and to rapidly
deliver electrical stimulation to the brain, are effective in reducing seizures in some patients …
deliver electrical stimulation to the brain, are effective in reducing seizures in some patients …
Epilepsy: new advances
Epilepsy affects 65 million people worldwide and entails a major burden in seizure-related
disability, mortality, comorbidities, stigma, and costs. In the past decade, important advances …
disability, mortality, comorbidities, stigma, and costs. In the past decade, important advances …