Heart-on-a-chip platforms and biosensor integration for disease modeling and phenotypic drug screening
Heart disease is the leading cause of death worldwide and imposes a significant burden on
healthcare systems globally. A major hurdle to the development of more effective …
healthcare systems globally. A major hurdle to the development of more effective …
NanoMEA: a tool for high-throughput, electrophysiological phenoty** of patterned excitable cells
Matrix nanotopographical cues are known to regulate the structure and function of somatic
cells derived from human pluripotent stem cell (hPSC) sources. High-throughput …
cells derived from human pluripotent stem cell (hPSC) sources. High-throughput …
Calcium handling maturation and adaptation to increased substrate stiffness in human iPSC-derived cardiomyocytes: The impact of full-length dystrophin deficiency
JM Pioner, L Santini, C Palandri, M Langione… - Frontiers in …, 2022 - frontiersin.org
Cardiomyocytes differentiated from human induced Pluripotent Stem Cells (hiPSC-CMs) are
a unique source for modelling inherited cardiomyopathies. In particular, the possibility of …
a unique source for modelling inherited cardiomyopathies. In particular, the possibility of …
Full-length dystrophin deficiency leads to contractile and calcium transient defects in human engineered heart tissues
Cardiomyopathy is currently the leading cause of death for patients with Duchenne muscular
dystrophy (DMD), a severe neuromuscular disorder affecting young boys. Animal models …
dystrophy (DMD), a severe neuromuscular disorder affecting young boys. Animal models …
Nanopatterned Nafion microelectrode arrays for in vitro cardiac electrophysiology
In this study, nanopatterned Nafion microelectrode arrays for in vitro cardiac
electrophysiology are reported. With the aim of defining sophisticated Nafion nanostructures …
electrophysiology are reported. With the aim of defining sophisticated Nafion nanostructures …
High-throughput contractility assay for human stem cell-derived cardiomyocytes: one beat closer to tracking heart muscle Dynamics
Like Fast Fourier Transforms, wavelet transforms are often used in image processing for
denoising, compression, and object detection. These transforms are similar in that they both …
denoising, compression, and object detection. These transforms are similar in that they both …
Role of Topographic Cues in Engineering the Muscle Niche
The microscopic world that cells inhabit is a complex milieu of biophysical structures,
chemicals, and forces. Each of these external stimuli helps to shape the behaviour of …
chemicals, and forces. Each of these external stimuli helps to shape the behaviour of …
At the roots of genetic cardiomyopathies: from 2D to 3D models based on human iPSC-derived cardiomyocytes
M Langione - 2023 - usiena-air.unisi.it
Human pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) represent a powerful
model for studying the mechanisms underlying inherited cardiomyopathies. Since hiPSCs …
model for studying the mechanisms underlying inherited cardiomyopathies. Since hiPSCs …