After decades of development, hot melt extrusion (HME) technology has matured as a well-
established pharmaceutical methodology. Through the process of extruding both drug and …

As the process analytical technology (PAT) mindset is progressively introduced and adopted
by the pharmaceutical companies, there is an increasing demand for effective and versatile …

Polymer degradation is a common problem in the extrusion process. In this work, Raman
spectroscopy, a robust, rapid, and non-destructive tool for in-line monitoring, was utilized to …

The absence of established quality benchmark experimental characterizations for validating
SMFs performance represents a substantial hurdle in the possible development of 4D …

Introduction: Currently, hot melt extrusion (HME) is a promising technology in the
pharmaceutical industry, as evidenced by its application to manufacture various FDA …

In the last few decades, hot-melt extrusion (HME) has emerged as a rapidly growing
technology in the pharmaceutical industry, due to its various advantages over other …

A key principle of develo** a new medicine is that quality should be built in, with a
thorough understanding of the product and the manufacturing process supported by …

The application of process analysis technology (PAT) to the hot melt extrusion (HME)
process serves two main purposes:(i) ensuring the quality of the final product and …

Raman spectroscopy is a very promising technique increasingly used in the pharmaceutical
industry. Due to its development and improved instrumental versatility achieved over recent …

The physical stability of solid-state forms in which drugs may exist is in some sense an
overlooked aspect. In an era where strategies such as amorphous solid dispersions or co …