Antibiotics in the clinical pipeline as of December 2022

MS Butler, IR Henderson, RJ Capon… - The Journal of …, 2023 - nature.com
The need for new antibacterial drugs to treat the increasing global prevalence of drug-
resistant bacterial infections has clearly attracted global attention, with a range of existing …

Antibiotics in the clinical pipeline in October 2019

MS Butler, DL Paterson - The Journal of antibiotics, 2020 - nature.com
The development of new and effective antibacterial drugs to treat multi-drug resistant (MDR)
bacteria, especially Gram-negative (G− ve) pathogens, is acknowledged as one of the …

QSPR analysis of distance-based structural indices for drug compounds in tuberculosis treatment

M Arockiaraj, FJH Campena, AB Greeni, MU Ghani… - Heliyon, 2024 - cell.com
Tuberculosis (TB) is one of the most contagious diseases that has a greater mortality rate
than HIV/AIDS and the cases of TB are feared to rise as a repercussion of the COVID-19 …

MDR tuberculosis treatment

J Espinosa-Pereiro, A Sánchez-Montalvá, ML Aznar… - Medicina, 2022 - mdpi.com
Multidrug-resistant (MDR) tuberculosis (TB), resistant to isoniazid and rifampicin, continues
to be one of the most important threats to controlling the TB epidemic. Over the last few …

Tuberculosis challenges: Resistance, co-infection, diagnosis, and treatment

M Heidary, M Shirani, M Moradi… - European Journal of …, 2022 - akjournals.com
Early diagnosis of tuberculosis (TB), followed by effective treatment, is the cornerstone of
global TB control efforts. An estimated 3 million cases of TB remain undetected each year …

Comprehensive review on mechanism of action, resistance and evolution of antimycobacterial drugs

A Chauhan, M Kumar, A Kumar, K Kanchan - Life sciences, 2021 - Elsevier
Tuberculosis is one of the deadliest infectious diseases existing in the world since ancient
times and still possesses serious threat across the globe. Each year the number of cases …

Synthesis and characterization of new N-acyl hydrazone derivatives of carprofen as potential tuberculostatic agents

IM Vlad, DC Nuță, MT Căproiu, F Dumitrașcu… - Antibiotics, 2024 - mdpi.com
N-acyl hydrazone (NAH) is recognized as a promising framework in drug design due to its
versatility, straightforward synthesis, and attractive range of biological activities, including …

[HTML][HTML] Tuberculosis: Past, present and future of the treatment and drug discovery research

AD Bendre, PJ Peters, J Kumar - Current research in pharmacology and …, 2021 - Elsevier
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium
tuberculosis. Despite decades of research driving advancements in drug development and …

Recent advances in nanoplatforms for the treatment of osteosarcoma

K Wu, B Yu, D Li, Y Tian, Y Liu, J Jiang - Frontiers in Oncology, 2022 - frontiersin.org
Osteosarcoma (OS) is the most common primary bone tumor in children and young people.
Traditional surgical excision combined with chemotherapy presents many limitations, such …

Recent advancements and developments in search of anti-tuberculosis agents: a quinquennial update and future directions

TM Dhameliya, KA Bhakhar, ND Gajjar, KA Patel… - Journal of Molecular …, 2022 - Elsevier
Tuberculosis (TB) has been considered as the highly chronic, contagious and infectious
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …