Taste buds: cells, signals and synapses

SD Roper, N Chaudhari - Nature Reviews Neuroscience, 2017 - nature.com
The past decade has witnessed a consolidation and refinement of the extraordinary
progress made in taste research. This Review describes recent advances in our …

Peripheral coding of taste

ER Liman, YV Zhang, C Montell - Neuron, 2014 - cell.com
Five canonical tastes, bitter, sweet, umami (amino acid), salty, and sour (acid), are detected
by animals as diverse as fruit flies and humans, consistent with a near-universal drive to …

An evolutionarily conserved gene family encodes proton-selective ion channels

YH Tu, AJ Cooper, B Teng, RB Chang, DJ Artiga… - Science, 2018 - science.org
Ion channels form the basis for cellular electrical signaling. Despite the scores of genetically
identified ion channels selective for other monatomic ions, only one type of proton-selective …

Cellular and neural responses to sour stimuli require the proton channel Otop1

B Teng, CE Wilson, YH Tu, NR Joshi, SC Kinnamon… - Current Biology, 2019 - cell.com
The sense of taste allows animals to sample chemicals in the environment prior to ingestion.
Of the five basic tastes, sour, the taste of acids, had remained among the most mysterious …

Taste transduction and channel synapses in taste buds

A Taruno, K Nomura, T Kusakizako, Z Ma… - … -European Journal of …, 2021 - Springer
The variety of taste sensations, including sweet, umami, bitter, sour, and salty, arises from
diverse taste cells, each of which expresses specific taste sensor molecules and associated …

An update on extra-oral bitter taste receptors

K Tuzim, A Korolczuk - Journal of translational medicine, 2021 - Springer
Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family
A G-protein coupled receptors (GPCRs), are of crucial importance in the perception of …

T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection

RJ Lee, G **ong, JM Kofonow, B Chen… - The Journal of …, 2012 - Am Soc Clin Investig
Innate and adaptive defense mechanisms protect the respiratory system from attack by
microbes. Here, we present evidence that the bitter taste receptor T2R38 regulates the …

The proton channel OTOP1 is a sensor for the taste of ammonium chloride

Z Liang, CE Wilson, B Teng, SC Kinnamon… - Nature …, 2023 - nature.com
Abstract Ammonium (NH4+), a breakdown product of amino acids that can be toxic at high
levels, is detected by taste systems of organisms ranging from C. elegans to humans and …

[HTML][HTML] Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system

P Holzer - Pharmacology & therapeutics, 2011 - Elsevier
Approximately 20 of the 30 mammalian transient receptor potential (TRP) channel subunits
are expressed by specific neurons and cells within the alimentary canal. They subserve …

Cholinergic chemosensory cells in the trachea regulate breathing

G Krasteva, BJ Canning, P Hartmann… - Proceedings of the …, 2011 - National Acad Sciences
In the epithelium of the lower airways, a cell type of unknown function has been termed
“brush cell” because of a distinctive ultrastructural feature, an apical tuft of microvilli …