The effective delivery of target-specific siRNA to the brain by exploiting the exosomes
derived from dendritic cells renders the paradigm shift for the prospective use of nanosized …

Cell-derived membrane vesicles (CMVs) are endogenous carriers transporting proteins and
nucleic acids between cells. They appear to play an important role in many disease …

Human induced pluripotent stem cells (iPSCs) have been generated with varied efficiencies
from multiple tissues. Yet, acquiring donor cells is, in most instances, an invasive procedure …

Stem cell therapy for cardiac disease is an exciting but highly controversial research area.
Strategies such as cell transplantation and reprogramming have demonstrated both …

The breakthrough of reprogramming human somatic cells was achieved in 2006 by the work
of Yamanaka and Takahashi. From this point, fibroblasts are the most commonly used …

The demonstration that dendritic cell (DC)‐derived exosomes can be exploited for targeted
RNAi delivery to the brain after systemic injection provides the first proof‐of‐concept for the …

BACKGROUND: Atopic dermatitis (AD) is an inflammatory skin disease affecting 10% to
20% of children and 1% to 3% of adults in industrialized countries. Enhanced expression of …

Prominent skin involvement is a defining characteristic of autoinflammatory disorders
caused by abnormal IL-1 signaling. However, the pathways and cell types that drive …

By forming a protective barrier, epidermal keratinocytes represent the first line of defense
against environmental insults. UVB radiation of the sun is a major challenge for the skin and …

Hidradenitis suppurativa (HS) is a chronic, inflammatory, debilitating, follicular disease of the
skin. Despite a high prevalence in the general population, the physiopathology of HS …