In this study, a hybrid modeling framework was developed for predicting size distribution and
content uniformity of granules in a bi-component wet granulation system with components of …

Abstract Model-driven design approaches have great potential to improve current
engineering workflows for wet granulation and other particulate processes. The key to model …

Size control in granulation is of great importance yet is often difficult to achieve. While
numerical and analytical models have previously been reported there is still no …

Abstract Model-driven design requires a well-calibrated model and therefore needs efficient
workflows to achieve this. This efficiency can be achieved with the identification of the critical …

Industry 4.0 is transforming the chemical engineering industry. With it, machine learning
(ML) is exploding, and a large variety of complex algorithms are being developed. One …

Modelling Spray Fluidised Bed Granulation Page 1 Modelling Spray Fluidised Bed Granulation
Sheikh Nabhan Ahmed Chemical and Biological Engineering University of Sheffield A thesis …

The spherical agglomeration process is gaining increasing interest in the pharmaceutical
industry as it has the ability to transform needle-like crystals into dense agglomerates that …

In wet granulation, controlling binder distribution is essential to manage particle growth.
Distribution nucleation occurs when droplets wet larger powder particles, forming nuclei …