The library of integrated network-based cellular signatures NIH program: system-level cataloging of human cells response to perturbations
The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common
Fund program that catalogs how human cells globally respond to chemical, genetic, and …
Fund program that catalogs how human cells globally respond to chemical, genetic, and …
Computational network biology: data, models, and applications
Biological entities are involved in intricate and complex interactions, in which uncovering the
biological information from the network concepts are of great significance. Benefiting from …
biological information from the network concepts are of great significance. Benefiting from …
Immunophenoty** of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19
Although most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–infected
individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer …
individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer …
Proteogenomics connects somatic mutations to signalling in breast cancer
Somatic mutations have been extensively characterized in breast cancer, but the effects of
these genetic alterations on the proteomic landscape remain poorly understood. Here we …
these genetic alterations on the proteomic landscape remain poorly understood. Here we …
The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins
Genomics, epigenomics, transcriptomics, proteomics and metabolomics efforts rapidly
generate a plethora of data on the activity and levels of biomolecules within mammalian …
generate a plethora of data on the activity and levels of biomolecules within mammalian …
A pan-cancer proteogenomic atlas of PI3K/AKT/mTOR pathway alterations
Y Zhang, PKS Ng, M Kucherlapati, F Chen, Y Liu… - Cancer cell, 2017 - cell.com
Molecular alterations involving the PI3K/AKT/mTOR pathway (including mutation, copy
number, protein, or RNA) were examined across 11,219 human cancers representing 32 …
number, protein, or RNA) were examined across 11,219 human cancers representing 32 …
Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders
Genetic liability to substance use disorders can be parsed into loci that confer general or
substance-specific addiction risk. We report a multivariate genome-wide association meta …
substance-specific addiction risk. We report a multivariate genome-wide association meta …
Lessons from the COVID-19 pandemic for advancing computational drug repurposing strategies
Responding quickly to unknown pathogens is crucial to stop uncontrolled spread of
diseases that lead to epidemics, such as the novel coronavirus, and to keep protective …
diseases that lead to epidemics, such as the novel coronavirus, and to keep protective …
A review of connectivity map and computational approaches in pharmacogenomics
Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of
Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for …
Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for …
Evaluation of large language models for discovery of gene set function
Gene set enrichment is a mainstay of functional genomics, but it relies on gene function
databases that are incomplete. Here we evaluate five large language models (LLMs) for …
databases that are incomplete. Here we evaluate five large language models (LLMs) for …