The first full publications on the biological effects of the diphosphonates, later renamed
bisphosphonates, appeared in 1969, so it is timely after 40 years to review the history of their …

Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …

This review describes the key discoveries over the last 15 years that have led to a clearer
understanding of the molecular mechanisms by which bisphosphonate drugs inhibit bone …

BACKGROUND Bisphosphonates currently are the most important class of antiresorptive
agents used in the treatment of metabolic bone diseases, including tumor‐associated …

Bisphosphonates (BPs) used as inhibitors of bone resorption all contain two phosphonate
groups attached to a single carbon atom, forming a “PCP” structure. The bisphosphonates …

The profound effects of the bisphosphonates on calcium metabolism were discovered over
30 years ago, and they are now well established as the major drugs used for the treatment of …

Bisphosphonates are currently the most important and effective class of anti-resorptive drugs
available, but the exact molecular mechanisms by which they inhibit osteoclast-mediated …

The discovery and development of the bisphosphonates (BPs) as a major class of drugs for
the treatment of bone diseases has been a fascinating journey that is still not over. In clinical …

Clodronate, alendronate, and other bisphosphonates are widely used in the treatment of
bone diseases characterized by excessive osteoclastic bone resorption. The exact …

Bisphosphonates are synthetic compounds characterized by a P–C–P group, and are thus
analogs of inorganic pyrophosphate. They are used in medicine mainly to inhibit bone …