OBJECTIVES: We conducted a systematic review to evaluate the association between
prenatal opioid use and congenital malformations. DATA SOURCES: We searched Medline …

Methadone is one of the most popular synthetic opioids in the world with some favorable
properties making it useful both in the treatment of moderate to severe pain and for opioid …

Importance Knowledge of health outcomes among opioid-exposed infants is limited,
particularly for those not diagnosed with neonatal opioid withdrawal syndrome (NOWS) …

Restless legs syndrome (RLS)/Willis-Ekbom disease (WED) is common during pregnancy,
affecting approximately one in five pregnant women in Western countries. Many report …

Pregnancy is an opportune time to identify opioid dependence, facilitate conversion to
opioid maintenance treatment, and coordinate care with specialists in addiction medicine …

Neonates exposed prenatally to opioids will often develop a collection of withdrawal signs
known as neonatal abstinence syndrome (NAS). The incidence of NAS has substantially …

Objective To review the literature about the association between breastfeeding and neonatal
abstinence syndrome (NAS) severity, need for pharmacologic treatment for NAS, and length …

Substance use contributes significantly to the global burden of disease. Growing numbers of
women use nicotine, alcohol, and illicit substances. Women are the most vulnerable to …

Background Naltrexone may provide a suitable alternative to methadone and
buprenorphine in the treatment of pregnant opioid-dependent women; however, little is …

Objective To conduct a meta-analysis to determine the association between prenatal drug
exposure and risk of sudden infant death syndrome (SIDS). Design Studies were searched …