Oxidative stress, which results in the damage of diverse biological molecules, is a ubiquitous
cellular process implicated in the etiology of many illnesses. The sulfhydryl-containing …

With the acceleration of population aging, nervous system diseases including Alzheimer's
disease (AD), Parkinson's disease (PD), Huntington's disease (HD), anxiety, depression …

Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …

Retinal ischemia is a common cause of visual impairment and blindness. At the cellular
level, ischemic retinal injury consists of a self-reinforcing destructive cascade involving …

Memantine, a partial antagonist of N-methyl-D-aspartate receptor (NMDAR), approved for
moderate to severe Alzheimer's disease (AD) treatment within the US and Europe under …

Introduction• Classifying TBI‐Clinical injury severity‐Focal injury or diffuse injury• Clinical
characteristics‐Coma, confusion and subacute impairments‐Imaging TBI‐Focal and diffuse …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

Neuronal death in cerebral ischemia is largely due to excitotoxic mechanisms, which are
known to activate the c-Jun N-terminal kinase (JNK) pathway. We have evaluated the …

The initial mechanical tissue disruption of spinal cord injury (SCI) is followed by a period of
secondary injury that increases the size of the lesion. The secondary injury has long been …

Glutamate is the principal excitatory neurotransmitter of the central nervous system, but
many studies have expanded its functional repertoire by showing that glutamate receptors …