Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis
K Kokubo, A Onodera, M Kiuchi, K Tsuji… - Frontiers in …, 2022 - frontiersin.org
Type 2 helper T (Th2) cells, a subset of CD4+ T cells, play an important role in the host
defense against pathogens and allergens by producing Th2 cytokines, such as interleukin-4 …
defense against pathogens and allergens by producing Th2 cytokines, such as interleukin-4 …
The cellular and molecular basis of CD69 function in anti-tumor immunity
R Koyama-Nasu, Y Wang, I Hasegawa… - International …, 2022 - academic.oup.com
Cancer immunotherapy utilizes our immune system to attack cancer cells and is an
extremely promising strategy for cancer treatment. Although immune-checkpoint blockade …
extremely promising strategy for cancer treatment. Although immune-checkpoint blockade …
Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia
Sensory neurons in the dorsal root ganglion (DRG) and trigeminal ganglion (TG) are
specialized to detect and transduce diverse environmental stimuli to the central nervous …
specialized to detect and transduce diverse environmental stimuli to the central nervous …
The functional requirement for CD69 in establishment of resident memory CD8+ T cells varies with tissue location
Recent studies have characterized populations of memory CD8+ T cells that do not
recirculate through the blood but are, instead, retained in nonlymphoid tissues. Such CD8+ …
recirculate through the blood but are, instead, retained in nonlymphoid tissues. Such CD8+ …
SARS-CoV-2 RNA elements share human sequence identity and upregulate hyaluronan via NamiRNA-enhancer network
W Li, S Yang, P Xu, D Zhang, Y Tong, L Chen, B Jia… - …, 2022 - thelancet.com
Summary Background Since late 2019, SARS-CoV-2 infection has resulted in COVID-19
accompanied by diverse clinical manifestations. However, the underlying mechanism of how …
accompanied by diverse clinical manifestations. However, the underlying mechanism of how …
Crucial role of CD69 in anti-tumor immunity through regulating the exhaustion of tumor-infiltrating T cells
Y Mita, MY Kimura, K Hayashizaki… - International …, 2018 - academic.oup.com
The introduction of immune checkpoint inhibitors in cancer treatment highlights the negative
regulation of anti-tumor immunity, such as effector T-cell exhaustion in the tumor …
regulation of anti-tumor immunity, such as effector T-cell exhaustion in the tumor …
Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2–induced lung exudative vasculitis and predicts COVID-19 severity
C Iwamura, K Hirahara, M Kiuchi… - Proceedings of the …, 2022 - National Acad Sciences
The mortality of coronavirus disease 2019 (COVID-19) is strongly correlated with pulmonary
vascular pathology accompanied by severe acute respiratory syndrome coronavirus 2 …
vascular pathology accompanied by severe acute respiratory syndrome coronavirus 2 …
Immunological memory in rheumatic inflammation—a roadblock to tolerance induction
Why do we still have no cure for chronic inflammatory diseases? One reason could be that
current therapies are based on the assumption that chronic inflammation is driven by …
current therapies are based on the assumption that chronic inflammation is driven by …
Immunological memories of the bone marrow
Memory for antigens once encountered is a hallmark of the immune system of vertebrates,
providing us with an immunity adapted to pathogens of our environment. Despite its …
providing us with an immunity adapted to pathogens of our environment. Despite its …
Crucial role for CD 69 in allergic inflammatory responses: CD 69‐Myl9 system in the pathogenesis of airway inflammation
MY Kimura, K Hayashizaki, K Tokoyoda… - Immunological …, 2017 - Wiley Online Library
CD 69 has been known as an early activation marker of lymphocytes; whereas, recent
studies demonstrate that CD 69 also has critical functions in immune responses. Early …
studies demonstrate that CD 69 also has critical functions in immune responses. Early …