Vitamin C—sources, physiological role, kinetics, deficiency, use, toxicity, and determination
M Doseděl, E Jirkovský, K Macáková, LK Krčmová… - Nutrients, 2021 - mdpi.com
Vitamin C (L-ascorbic acid) has been known as an antioxidant for most people. However, its
physiological role is much larger and encompasses very different processes ranging from …
physiological role is much larger and encompasses very different processes ranging from …
Neuroprotective effect of antioxidants in the brain
KH Lee, M Cha, BH Lee - International journal of molecular sciences, 2020 - mdpi.com
The brain is vulnerable to excessive oxidative insults because of its abundant lipid content,
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …
[HTML][HTML] Ascorbic acid metabolism and functions: A comparison of plants and mammals
N Smirnoff - Free Radical Biology and Medicine, 2018 - Elsevier
Ascorbic acid is synthesised by eukaryotes, the known exceptions being primates and some
other animal groups which have lost functional gulonolactone oxidase. Prokaryotes do not …
other animal groups which have lost functional gulonolactone oxidase. Prokaryotes do not …
Oxidative stress and cognitive decline: the neuroprotective role of natural antioxidants
Free-radicals (Oxygen and Nitrogen species) are formed in mitochondria during the
oxidative phosphorylation. Their high reactivity, due to not-engaged electrons, leads to an …
oxidative phosphorylation. Their high reactivity, due to not-engaged electrons, leads to an …
Metabolism and regulation of ascorbic acid in fruits
X Zheng, M Gong, Q Zhang, H Tan, L Li, Y Tang, Z Li… - Plants, 2022 - mdpi.com
Ascorbic acid, also known as vitamin C, is a vital antioxidant widely found in plants. Plant
fruits are rich in ascorbic acid and are the primary source of human intake of ascorbic acid …
fruits are rich in ascorbic acid and are the primary source of human intake of ascorbic acid …
The role of SLC transporters for brain health and disease
The brain exchanges nutrients and small molecules with blood via the blood–brain barrier
(BBB). Approximately 20% energy intake for the body is consumed by the brain. Glucose is …
(BBB). Approximately 20% energy intake for the body is consumed by the brain. Glucose is …
The epigenetic role of vitamin C in neurodevelopment
The maternal diet during pregnancy is a key determinant of offspring health. Early studies
have linked poor maternal nutrition during gestation with a propensity for the development of …
have linked poor maternal nutrition during gestation with a propensity for the development of …
Neurobiology of vitamin C: Expanding the focus from antioxidant to endogenous neuromodulator
SJ Ballaz, GV Rebec - Pharmacological research, 2019 - Elsevier
Ascorbic acid (AA) is a water-soluble vitamin (C) found in all bodily organs. Most mammals
synthesize it, humans are required to eat it, but all mammals need it for healthy functioning …
synthesize it, humans are required to eat it, but all mammals need it for healthy functioning …
The sodium-dependent ascorbic acid transporter family SLC23
M Bürzle, Y Suzuki, D Ackermann, H Miyazaki… - Molecular aspects of …, 2013 - Elsevier
Transporters for vitamin C and its oxidized form dehydroascorbic acid (DHA) are crucial to
maintain physiological concentrations of this important vitamin that is used in a variety of …
maintain physiological concentrations of this important vitamin that is used in a variety of …
Regulation of vitamin C homeostasis during deficiency
Large cross-sectional population studies confirm that vitamin C deficiency is common in
humans, affecting 5%–10% of adults in the industrialized world. Moreover, significant …
humans, affecting 5%–10% of adults in the industrialized world. Moreover, significant …