The use of many halogenated alkanes such as carbon tetrachloride (CCl4), chloroform
(CHCl3) or iodoform (CHI3), has been banned or severely restricted because of their distinct …

The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …

A fundamental property of animal cells is the ability to regulate their own cell volume. Even
under hypotonic stress imposed by either decreased extracellular or increased intracellular …

In humans and experimental models of renal ischemia, tubular cells in various nephron
segments undergo necrotic and/or apoptotic cell death. Various factors, including nucleotide …

Acute pancreatitis is a disease of variable severity in which some patients experience mild,
self-limited attacks, whereas others manifest a severe, highly morbid, and frequently lethal …

Nanosecond pulsed electric field (nsPEF) is a novel modality for permeabilization of
membranous structures and intracellular delivery of xenobiotics. We hypothesized that …

Drug-induced liver injury is a significant and still unresolved clinical problem. Limitations to
knowledge about the mechanisms of toxicity render incomplete the detection of hepatotoxic …

Gap junction channels and hemichannels formed of connexin subunits are found in most
cell types in vertebrates. Gap junctions connect cells via channels not open to the …

Mammalian cells exposed to electric field pulses of nanosecond duration (nsPEF; 60-ns,
12kV/cm) experienced a profound and long-lasting increase in passive electrical …

The cytotoxic effect of microcin E492, a low-molecular-mass channel-forming bacteriocin
(7,887 Da) produced by a strain of Klebsiella pneumoniae, was characterized in HeLa cells …