The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Obesity, insulin resistance, type 2 diabetes mellitus and cardiovascular disease form a
metabolic disease continuum that has seen a dramatic increase in prevalence in developed …

Different studies corroborate a role for ceramide synthases and their downstream products,
ceramides, in modulation of apoptosis and autophagy in the context of cancer. These …

Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Ectopic lipid deposition and altered mitochondrial dynamics contribute to the development of
obesity and insulin resistance. However, the mechanistic link between these processes …

Ceramide accumulation is a hallmark in the manifestation of numerous obesity-related
diseases, such as type 2 diabetes mellitus and atherosclerosis. Until the early 2000s …

Embraced with apolipoproteins (Apo) B and Apo E, triglyceride-enriched very-low-density
lipoprotein (VLDL) is secreted by the liver into circulation, mainly during post-meal hours …

Growing evidence suggests that ceramides play an important role in the development of
atherosclerotic and valvular heart disease. Ceramides are biologically active sphingolipids …