Pharmacological properties of chalcones: A review of preclinical including molecular mechanisms and clinical evidence

B Salehi, C Quispe, I Chamkhi, N El Omari… - Frontiers in …, 2021 - frontiersin.org
Chalcones are among the leading bioactive flavonoids with a therapeutic potential
implicated to an array of bioactivities investigated by a series of preclinical and clinical …

[HTML][HTML] Chalcone scaffolds, bioprecursors of flavonoids: Chemistry, bioactivities, and pharmacokinetics

M Rudrapal, J Khan, AAB Dukhyil, RMII Alarousy… - Molecules, 2021 - mdpi.com
Chalcones are secondary metabolites belonging to the flavonoid (C6-C3-C6 system) family
that are ubiquitous in edible and medicinal plants, and they are bioprecursors of plant …

Psoralea corylifolia L.: a comprehensive review of its botany, traditional uses, phytochemistry, pharmacology, toxicology, quality control and pharmacokinetics

L Chen, S Chen, P Sun, X Liu, Z Zhan, J Wang - Chinese medicine, 2023 - Springer
Abstract Psoralea corylifolia L.(PCL), referred to as “Bu-gu-zhi” in Chinese, has great
medicinal values since ancient times. PCL is the dried ripe fruit of Psoralea corylifolia L …

Promising anti-inflammatory effects of chalcones via inhibition of cyclooxygenase, prostaglandin E2, inducible NO synthase and nuclear factor κb activities

H ur Rashid, Y Xu, N Ahmad, Y Muhammad… - Bioorganic Chemistry, 2019 - Elsevier
Abstract Chalcones (1, 3-Diphenyl-2-propen-1-one) consist of a three carbon α, β-
unsaturated carbonyl system and act as precursors for the biosynthesis of flavonoids in …

Current applications of Suzuki–Miyaura coupling reaction in the total synthesis of natural products: an update

A Taheri Kal Koshvandi, MM Heravi… - Applied …, 2018 - Wiley Online Library
Suzuki‐Miyaura Coupling Reaction (SMCR) has been extensively used in the total synthesis
of natural products. We underscored these achievements in a report published in …

Isolation and biological activity of natural chalcones based on antibacterial mechanism classification

S Wang, C Li, L Zhang, B Sun, Y Cui, F Sang - Bioorganic & Medicinal …, 2023 - Elsevier
Bacterial infection, which is still one of the leading causes of death in humans, poses an
enormous threat to the worldwide public health system. Antibiotics are the primary …

The role of chalcones in suppression of NF-κB-mediated inflammation and cancer

VR Yadav, S Prasad, B Sung, BB Aggarwal - International …, 2011 - Elsevier
Although consumption of fruits, vegetables, spices, cereals and pulses has been associated
with lower incidence of cancer and other chronic diseases, how these dietary agents and …

The Chemical Constituents and Bioactivities of Psoralea corylifolia Linn.: A Review

X Zhang, W Zhao, Y Wang, J Lu… - The American journal of …, 2016 - World Scientific
Psoralea corylifolia Linn.(P. corylifolia) is an important medicinal plant with thousands of
years of clinical application. It has been widely used in many traditional Chinese medicine …

miR-124 and Parkinson's disease: A biomarker with therapeutic potential

E Angelopoulou, YN Paudel, C Piperi - Pharmacological Research, 2019 - Elsevier
Parkinson's disease (PD) is a multifactorial disorder, attributed to a complex interplay
between genetic and epigenetic factors. Although the exact etiology of the disease remains …

Prenylation of aromatic compounds, a key diversification of plant secondary metabolites

K Yazaki, K Sasaki, Y Tsurumaru - Phytochemistry, 2009 - Elsevier
Prenylation plays a major role in the diversification of aromatic natural products, such as
phenylpropanoids, flavonoids, and coumarins. This biosynthetic reaction represents the …