Abstract Progesterone Receptor Membrane Component 1 (PGRMC1) is a heme-binding
protein that has been implicated in a wide range of cell and tissue functions, including …

Cancer is one of the most common causes of death worldwide, and its development is a
result of the complex interaction of genetic factors, environmental cues, and aging. Hormone …

Progesterone (PRG) is a key cyclical reproductive hormone that has a significant impact on
female organs in vertebrates. It is mainly produced by the corpus luteum of the ovaries, but …

Sigma receptors are non-opiate/non-phencyclidine receptors that bind progesterone and/or
heme and also several unrelated xenobiotics/chemicals. They reside in the plasma …

Simple Summary Progesterone (P4) via PGRMC1/NENF may stimulate the proliferation and
invasion of colorectal cancer DLD-1 and HT-29 cells. PGRMC1 inhibition abolishes the …

Progesterone receptor membrane component 1 (PGRMC1) binds heme via a surface-
exposed site and displays some structural resemblance to cytochrome b5 despite their …

Objective Triple-negative breast cancer (TNBC) is the most malignant form of breast cancer
with increasing incidence and mortality worldwide. The progesterone receptor membrane …

Mononuclear cytotrophoblasts (CTs) differentiate and fuse to form multinuclear
syncytiotrophoblasts (STs), which produce human chorionic gonadotropin (hCG) and …

Progestins used in hormonal contraceptives and menopausal hormone therapy (MHT) have
been linked to increased breast cancer risk. Whether the association holds for all progestins …

An inappropriate response to progestogens in the human endometrium can result in fertility
issues and jeopardize progestin-based treatments against pathologies such as …