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Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …
Lupeol and its derivatives as anticancer and anti-inflammatory agents: Molecular mechanisms and therapeutic efficacy
K Liu, X Zhang, L **e, M Deng, H Chen, J Song… - Pharmacological …, 2021 - Elsevier
Lupeol is a natural triterpenoid that widely exists in edible fruits and vegetables, and
medicinal plants. In the last decade, a plethora of studies on the pharmacological activities …
medicinal plants. In the last decade, a plethora of studies on the pharmacological activities …
Triterpenes as potentially cytotoxic compounds
M Chudzik, I Korzonek-Szlacheta, W Król - Molecules, 2015 - mdpi.com
Triterpenes are compounds of natural origin, which have numerously biological activities:
anti-cancer properties, anti-inflammatory, anti-oxidative, anti-viral, anti-bacterial and anti …
anti-cancer properties, anti-inflammatory, anti-oxidative, anti-viral, anti-bacterial and anti …
Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance
T Biswas, UN Dwivedi - Protoplasma, 2019 - Springer
The saponins are a diverse class of natural products, with a broad scale distribution across
different plant species. Chemically characterized as triterpenoid glycosides, they posses a …
different plant species. Chemically characterized as triterpenoid glycosides, they posses a …
Molecular pharmacology and therapeutic advances of the pentacyclic triterpene lupeol
AAM Sohag, MT Hossain, MA Rahaman, P Rahman… - Phytomedicine, 2022 - Elsevier
Background Plant triterpenoids are major sources of nutraceuticals that provide many health
benefits to humans. Lupeol is one of the pentacyclic dietary triterpenoids commonly found in …
benefits to humans. Lupeol is one of the pentacyclic dietary triterpenoids commonly found in …
[HTML][HTML] Nature-derived compounds modulating Wnt/β-catenin pathway: a preventive and therapeutic opportunity in neoplastic diseases
The Wnt/β-catenin signaling is a conserved pathway that has a crucial role in embryonic and
adult life. Dysregulation of the Wnt/β-catenin pathway has been associated with diseases …
adult life. Dysregulation of the Wnt/β-catenin pathway has been associated with diseases …
[HTML][HTML] Lupeol alleviates autoimmune myocarditis by suppressing macrophage pyroptosis and polarization via PPARα/LACC1/NF-κB signaling pathway
Y **ong, Z Zhang, S Liu, L Shen, L Zheng, L Ding, L Liu… - Phytomedicine, 2024 - Elsevier
Background Autoimmune myocarditis, with increasing incidence and limited therapeutic
strategies, is in urgent need to explore its underlying mechanisms and effective drugs …
strategies, is in urgent need to explore its underlying mechanisms and effective drugs …
In vitro evaluation of anticancer potentials of lupeol isolated from Elephantopus scaber L. on MCF-7 cell line
D Pitchai, A Roy, C Ignatius - Journal of advanced pharmaceutical …, 2014 - journals.lww.com
Lupeol is a triterpenoid, present in most of the medicinally effective plants and possess a
wide range of biological activity against human diseases. The present study aims at …
wide range of biological activity against human diseases. The present study aims at …
Suppression of EGFR/STAT3 activity by lupeol contributes to the induction of the apoptosis of human non-small cell lung cancer cells
TR Min, HJ Park, KT Ha, GY Chi… - … journal of oncology, 2019 - spandidos-publications.com
The aim of this study was to investigate the underlying mechanisms responsible for the
anticancer effects of lupeol on human non-small cell lung cancer (NSCLC). MTT assay and …
anticancer effects of lupeol on human non-small cell lung cancer (NSCLC). MTT assay and …
Lupeol and its role in chronic diseases
FS Tsai, LW Lin, CR Wu - Drug discovery from mother nature, 2016 - Springer
Lupeol belongs to pentacyclic lupane-type triterpenes and exhibits in edible vegetables,
fruits and many plants. Many researches indicated that lupeol possesses many beneficial …
fruits and many plants. Many researches indicated that lupeol possesses many beneficial …