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[HTML][HTML] The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality
Executive summary Liver diseases have become a major health threat across Europe, and
the face of European hepatology is changing due to the cure of viral hepatitis C and the …
the face of European hepatology is changing due to the cure of viral hepatitis C and the …
The stiffness of living tissues and its implications for tissue engineering
The past 20 years have witnessed ever-growing evidence that the mechanical properties of
biological tissues, from nanoscale to macroscale dimensions, are fundamental for cellular …
biological tissues, from nanoscale to macroscale dimensions, are fundamental for cellular …
Assessing the performance of ChatGPT in answering questions regarding cirrhosis and hepatocellular carcinoma
Background/Aims Patients with cirrhosis and hepatocellular carcinoma (HCC) require
extensive and personalized care to improve outcomes. ChatGPT (Generative Pre-trained …
extensive and personalized care to improve outcomes. ChatGPT (Generative Pre-trained …
[HTML][HTML] The microbiota in cirrhosis and its role in hepatic decompensation
Cirrhosis–the common end-stage of chronic liver disease–is associated with a cascade of
events, of which intestinal bacterial overgrowth and dysbiosis are central. Bacterial toxins …
events, of which intestinal bacterial overgrowth and dysbiosis are central. Bacterial toxins …
β blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo …
Background Clinical decompensation of cirrhosis is associated with poor prognosis.
Clinically significant portal hypertension (CSPH), defined by a hepatic venous pressure …
Clinically significant portal hypertension (CSPH), defined by a hepatic venous pressure …
Carvedilol reduces the risk of decompensation and mortality in patients with compensated cirrhosis in a competing-risk meta-analysis
Background & Aims Whether non-selective β-blockers can prevent decompensation of
cirrhosis warrants clarification. Carvedilol might be particularly effective since its intrinsic …
cirrhosis warrants clarification. Carvedilol might be particularly effective since its intrinsic …
EASL clinical practice guidelines: management of hepatocellular carcinoma
Liver cancer is the fifth most common cancer and the second most frequent cause of cancer-
related death globally. Hepatocellular carcinoma represents about 90% of primary liver …
related death globally. Hepatocellular carcinoma represents about 90% of primary liver …
Towards a new definition of decompensated cirrhosis
There is a universal agreement that the occurrence of clinical complications, such as ascites,
hepatic encephalopathy, gastrointestinal bleeding, and jaundice mark the transition from the …
hepatic encephalopathy, gastrointestinal bleeding, and jaundice mark the transition from the …
Hepatic stellate cells as key target in liver fibrosis
Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more
than one million deaths annually via development of cirrhosis, although no antifibrotic …
than one million deaths annually via development of cirrhosis, although no antifibrotic …
FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2
Objective Follistatin-like protein 1 (FSTL1) is widely recognised as a secreted glycoprotein,
but its role in modulating macrophage-related inflammation during liver fibrosis has not been …
but its role in modulating macrophage-related inflammation during liver fibrosis has not been …