Organ development and homeostasis involve dynamic interactions between individual cells
that collectively regulate tissue architecture and function. To ensure the highest tissue …

Understanding the pathophysiology of endometriosis is changing our diagnosis and
treatment. Endometriosis lesions are clones of specific cells, with variable characteristics as …

Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …

Acquired mutations are pervasive across normal tissues. However, understanding of the
processes that drive transformation of certain clones to cancer is limited. Here we study this …

Endometriosis is a common condition in women that causes chronic pain and infertility and
is associated with an elevated risk of ovarian cancer. We profiled transcriptomes of> …

Human epithelial tissues accumulate cancer-driver mutations with age,,,,,,,–, yet tumour
formation remains rare. The positive selection of these mutations suggests that they alter the …

The extent of somatic mutation and clonal selection in the human bladder remains unknown.
We sequenced 2097 bladder microbiopsies from 20 individuals using targeted (n= 1914 …

The etiopathogenesis of endometriosis is a multifactorial process resulting in a
heterogeneous disease. Considering that endometriosis etiology and pathogenesis are still …

Mutation accumulation in somatic cells contributes to cancer development and is proposed
as a cause of aging. DNA polymerases Pol ε and Pol δ replicate DNA during cell division …

The colorectal adenoma–carcinoma sequence has provided a paradigmatic framework for
understanding the successive somatic genetic changes and consequent clonal expansions …