Protein networks in the maturation of human iron–sulfur proteins
The biogenesis of iron–sulfur (Fe–S) proteins in humans is a multistage process occurring in
different cellular compartments. The mitochondrial iron–sulfur cluster (ISC) assembly …
different cellular compartments. The mitochondrial iron–sulfur cluster (ISC) assembly …
Emerging therapeutic targets for treatment of leishmaniasis
S Sundar, B Singh - Expert opinion on therapeutic targets, 2018 - Taylor & Francis
Introduction: Parasitic diseases that pose a threat to human life include leishmaniasis–
caused by protozoan parasite Leishmania species. Existing drugs have limitations due to …
caused by protozoan parasite Leishmania species. Existing drugs have limitations due to …
Iron and heme metabolism at the leishmania–host interface
Species of the protozoan Leishmania are causative agents of human leishmaniasis, a
disease that results in significant death, disability, and disfigurement around the world. The …
disease that results in significant death, disability, and disfigurement around the world. The …
ABC transporter inhibition by beauvericin partially overcomes drug resistance in Leishmania tropica
Leishmaniasis is a neglected tropical disease infecting the world's poorest populations.
Miltefosine (ML) remains the primary oral drug against the cutaneous form of leishmaniasis …
Miltefosine (ML) remains the primary oral drug against the cutaneous form of leishmaniasis …
Carbohydrate-naphthalene diimide conjugates as potential antiparasitic drugs: Synthesis, evaluation and structure-activity studies
M Zuffo, A Stucchi, J Campos-Salinas… - European journal of …, 2019 - Elsevier
The neglected tropical diseases Human African Trypanosomiasis and leishmaniasis are
caused by infection with trypanosomatid parasites Trypanosoma brucei and Leishmania …
caused by infection with trypanosomatid parasites Trypanosoma brucei and Leishmania …
Glutaredoxins and iron-sulfur protein biogenesis at the interface of redox biology and iron metabolism
U Mühlenhoff, JJ Braymer, S Christ… - Biological …, 2020 - degruyter.com
The physiological roles of the intracellular iron and redox regulatory systems are intimately
linked. Iron is an essential trace element for most organisms, yet elevated cellular iron levels …
linked. Iron is an essential trace element for most organisms, yet elevated cellular iron levels …
TransLeish: Identification of membrane transporters essential for survival of intracellular Leishmania parasites in a systematic gene deletion screen
A Albuquerque-Wendt, C McCoy, R Neish… - Nature …, 2025 - nature.com
For the protozoan parasite Leishmania, completion of its life cycle requires sequential
adaptation of cellular physiology and nutrient scavenging mechanisms to the different …
adaptation of cellular physiology and nutrient scavenging mechanisms to the different …
Leishmania heme uptake involves LmFLVCRb, a novel porphyrin transporter essential for the parasite
Leishmaniasis comprises a group of neglected diseases caused by the protozoan parasite
Leishmania spp. As is the case for other trypanosomatid parasites, Leishmania is …
Leishmania spp. As is the case for other trypanosomatid parasites, Leishmania is …
[HTML][HTML] The ultimate fate determinants of drug induced cell-death mechanisms in Trypanosomatids
P Das, S Saha, S BoseDasgupta - International Journal for Parasitology …, 2021 - Elsevier
Chemotherapy constitutes a major part of modern-day therapy for infectious and chronic
diseases. A drug is said to be effective if it can inhibit its target, induce stress, and thereby …
diseases. A drug is said to be effective if it can inhibit its target, induce stress, and thereby …
Hemoglobin Endocytosis and Intracellular Trafficking: A Novel Way of Heme Acquisition by Leishmania
Leishmania species are causative agents of human leishmaniasis, affecting 12 million
people annually. Drugs available for leishmaniasis are toxic, and no vaccine is available …
people annually. Drugs available for leishmaniasis are toxic, and no vaccine is available …