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Different treatment strategies and molecular features between right-sided and left-sided colon cancers
H Shen, J Yang, Q Huang, MJ Jiang… - World journal of …, 2015 - pmc.ncbi.nlm.nih.gov
The colon is derived from the embryological midgut and hindgut separately, with the right
colon and left colon having different features with regards to both anatomical and …
colon and left colon having different features with regards to both anatomical and …
Diagnosis of Lynch syndrome and strategies to distinguish Lynch-related tumors from sporadic MSI/dMMR tumors
J Leclerc, C Vermaut, MP Buisine - Cancers, 2021 - mdpi.com
Simple Summary Microsatellite instability (MSI) is a hallmark of Lynch syndrome (LS)-related
tumors but is not specific, as most of MSI/mismatch repair-deficient (dMMR) tumors are …
tumors but is not specific, as most of MSI/mismatch repair-deficient (dMMR) tumors are …
BRAF V600E mutation-specific antibody: a review
LL Ritterhouse, JA Barletta - Seminars in diagnostic pathology, 2015 - Elsevier
The significance of BRAF mutations in neoplasia was first recognized in 2002 when
mutations were discovered in a broad range of cancers. Numerous subsequent studies …
mutations were discovered in a broad range of cancers. Numerous subsequent studies …
The current value of determining the mismatch repair status of colorectal cancer: a rationale for routine testing
E Ryan, K Sheahan, B Creavin, HM Mohan… - Critical reviews in …, 2017 - Elsevier
Colorectal Cancer (CRC) is the third most prevalent cancer in men and women. Up to 15%
of CRCs display microsatellite instability (MSI). MSI is reflective of a deficient mismatch …
of CRCs display microsatellite instability (MSI). MSI is reflective of a deficient mismatch …
Comprehensive immunohistochemical study of programmed cell death ligand 1 (PD-L1): analysis in 5536 cases revealed consistent expression in trophoblastic …
S Inaguma, Z Wang, J Lasota… - The American journal …, 2016 - journals.lww.com
Programmed cell death 1/programmed cell death ligand (PD-1/PD-Ls) axis is crucial for the
modulation of immune responses and self-tolerance. Also, aberrant PD-L1 expression on …
modulation of immune responses and self-tolerance. Also, aberrant PD-L1 expression on …
[HTML][HTML] Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomas
S Inaguma, J Lasota, Z Wang, A Felisiak-Golabek… - Modern Pathology, 2017 - Elsevier
Abstract The CD274 (PD-L1)/PDCD1 (PD-1) pathway is crucial for the modulation of
immune responses and self-tolerance. Aberrantly expressed CD274 allows tumor cells to …
immune responses and self-tolerance. Aberrantly expressed CD274 allows tumor cells to …
Practical immunohistochemistry in neoplastic pathology of the gastrointestinal tract, liver, biliary tract, and pancreas
HL Wang, CJ Kim, J Koo, W Zhou… - … of pathology & …, 2017 - meridian.allenpress.com
Context.—Immunomarkers with diagnostic, therapeutic, or prognostic values have been
increasingly used to maximize the benefits of clinical management of patients with …
increasingly used to maximize the benefits of clinical management of patients with …
Comprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its …
S Inaguma, Z Wang, J Lasota, M Onda… - …, 2017 - pmc.ncbi.nlm.nih.gov
Mesothelin (MSLN) is a glycophosphatidylinositol (GPI)-linked cell surface protein highly
expressed in several types of malignant tumors sometimes in association with increased …
expressed in several types of malignant tumors sometimes in association with increased …
BRAFV600E immunohistochemistry can reliably substitute BRAF molecular testing in the Lynch syndrome screening algorithm in colorectal cancer
F Grillo, M Paudice, S Pigozzi, M Dono… - …, 2024 - Wiley Online Library
Aims The Lynch syndrome (LS) screening algorithm requires BRAF testing as a fundamental
step to distinguish sporadic from LS‐associated colorectal carcinomas (CRC). BRAF testing …
step to distinguish sporadic from LS‐associated colorectal carcinomas (CRC). BRAF testing …
Identification of novel natural drug candidates against BRAF mutated carcinoma; An integrative in-silico structure-based pharmacophore modeling and virtual …
FA Dain Md Opo, AA Alsaiari… - Frontiers in …, 2022 - frontiersin.org
The BRAF gene is responsible for transferring signals from outside of the cell to inside of the
nucleus by converting a protein namely B-Raf through the RAS/MAPK pathway. This …
nucleus by converting a protein namely B-Raf through the RAS/MAPK pathway. This …