T cells and adaptive immunity to Mycobacterium tuberculosis in humans
The adaptive immune response mediated by T cells is critical for control of Mycobacterium
tuberculosis (M. tuberculosis) infection in humans. However, the M. tuberculosis antigens …
tuberculosis (M. tuberculosis) infection in humans. However, the M. tuberculosis antigens …
Immunological biomarkers of tuberculosis
Currently there are no sufficiently validated biomarkers to aid the evaluation of new
tuberculosis vaccine candidates, the improvement of tuberculosis diagnostics or the …
tuberculosis vaccine candidates, the improvement of tuberculosis diagnostics or the …
Vaccines against tuberculosis: where are we and where do we need to go?
In this review we discuss recent progress in the development, testing, and clinical evaluation
of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has …
of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has …
Th1 and Th17 cells in tuberculosis: protection, pathology, and biomarkers
IV Lyadova, AV Panteleev - Mediators of inflammation, 2015 - Wiley Online Library
The outcome of Mycobacterium tuberculosis (Mtb) infection ranges from a complete
pathogen clearance through asymptomatic latent infection (LTBI) to active tuberculosis (TB) …
pathogen clearance through asymptomatic latent infection (LTBI) to active tuberculosis (TB) …
Variability in tuberculosis granuloma T cell responses exists, but a balance of pro-and anti-inflammatory cytokines is associated with sterilization
Lung granulomas are the pathologic hallmark of tuberculosis (TB). T cells are a major
cellular component of TB lung granulomas and are known to play an important role in …
cellular component of TB lung granulomas and are known to play an important role in …
Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load
CL Day, DA Abrahams, L Lerumo… - The Journal of …, 2011 - journals.aai.org
High Ag load in chronic viral infections has been associated with impairment of Ag-specific T
cell responses; however, the relationship between Ag load in chronic Mycobacterium …
cell responses; however, the relationship between Ag load in chronic Mycobacterium …
Functional Signatures of Human CD4 and CD8 T Cell Responses to Mycobacterium tuberculosis
T Prezzemolo, G Guggino, MP La Manna… - Frontiers in …, 2014 - frontiersin.org
With 1.4 million deaths and 8.7 million new cases in 2011, tuberculosis (TB) remains a
global health care problem and together with HIV and Malaria represents one of the three …
global health care problem and together with HIV and Malaria represents one of the three …
Polyfunctional responses by human T cells result from sequential release of cytokines
The release of cytokines by T cells defines a significant part of their functional activity in vivo,
and their ability to produce multiple cytokines has been associated with beneficial immune …
and their ability to produce multiple cytokines has been associated with beneficial immune …
Update on tuberculosis biomarkers: from correlates of risk, to correlates of active disease and of cure from disease
D Goletti, MR Lee, JY Wang, N Walter… - …, 2018 - Wiley Online Library
Tuberculosis (TB) remains a devastating disease, yet despite its enormous toll on global
health, tools to control TB are insufficient and often outdated. TB Biomarkers (TB‐BM) would …
health, tools to control TB are insufficient and often outdated. TB Biomarkers (TB‐BM) would …
Latent tuberculosis infection: myths, models, and molecular mechanisms
The aim of this review is to present the current state of knowledge on human latent
tuberculosis infection (LTBI) based on clinical studies and observations, as well as …
tuberculosis infection (LTBI) based on clinical studies and observations, as well as …