The role of m6A RNA methylation in cancer metabolism
Y An, H Duan - Molecular cancer, 2022 - Springer
Metabolic reprogramming is one of the main characteristics of malignant tumors, which is
due to the flexible changes of cell metabolism that can meet the needs of cell growth and …
due to the flexible changes of cell metabolism that can meet the needs of cell growth and …
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects
The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …
Signal pathways of melanoma and targeted therapy
W Guo, H Wang, C Li - Signal transduction and targeted therapy, 2021 - nature.com
Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …
The role of m6A modification in the biological functions and diseases
X Jiang, B Liu, Z Nie, L Duan, Q **ong, Z **… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
RNA in cancer
GJ Goodall, VO Wickramasinghe - Nature Reviews Cancer, 2021 - nature.com
While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …
The epitranscriptome beyond m6A
Following its transcription, RNA can be modified by> 170 chemically distinct types of
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …
The potential role of N7-methylguanosine (m7G) in cancer
Y Luo, Y Yao, P Wu, X Zi, N Sun, J He - Journal of hematology & oncology, 2022 - Springer
Abstract N 7-methylguanosine (m7G), one of the most prevalent RNA modifications, has
recently attracted significant attention. The m7G modification actively participates in …
recently attracted significant attention. The m7G modification actively participates in …
[HTML][HTML] METTL3 inhibits antitumor immunity by targeting m6A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer
Background & Aims N 6-Methyladenosine (m 6 A) is the most prevalent RNA modification
and recognized as an important epitranscriptomic mechanism in colorectal cancer (CRC) …
and recognized as an important epitranscriptomic mechanism in colorectal cancer (CRC) …
A comprehensive review of m6A/m6Am RNA methyltransferase structures
S Oerum, V Meynier, M Catala, C Tisné - Nucleic acids research, 2021 - academic.oup.com
Gene expression is regulated at many levels including co-or post-transcriptionally, where
chemical modifications are added to RNA on riboses and bases. Expression control via RNA …
chemical modifications are added to RNA on riboses and bases. Expression control via RNA …
[HTML][HTML] G3BP1 is a tunable switch that triggers phase separation to assemble stress granules
The mechanisms underlying ribonucleoprotein (RNP) granule assembly, including the basis
for establishing and maintaining RNP granules with distinct composition, are unknown. One …
for establishing and maintaining RNP granules with distinct composition, are unknown. One …