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Myeloid cell-targeted therapies for solid tumours
Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …
where they have a variety of functions, ranging from immunosuppressive to …
Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation
Autophagy is well equipped functionally to isolate microbial pathogens in autophagosomes
and to carry out their clearance by dismemberment in the course of catabolic processes in …
and to carry out their clearance by dismemberment in the course of catabolic processes in …
LAMP2A, LAMP2B and LAMP2C: similar structures, divergent roles
L Qiao, J Hu, X Qiu, C Wang, J Peng, C Zhang… - Autophagy, 2023 - Taylor & Francis
ABSTRACT LAMP2 (lysosomal associated membrane protein 2) is one of the major protein
components of the lysosomal membrane. There currently exist three LAMP2 isoforms …
components of the lysosomal membrane. There currently exist three LAMP2 isoforms …
[HTML][HTML] Chaperone-mediated autophagy and endosomal microautophagy: Jointed by a chaperone
A variety of mechanisms deliver cytosolic materials to the lysosomal compartment for
degradation through autophagy. Here, we focus on two autophagic pathways, the …
degradation through autophagy. Here, we focus on two autophagic pathways, the …
[HTML][HTML] Fc gamma receptors and their role in antigen uptake, presentation, and T cell activation
The cellular uptake, intracellular processing, and presentation of foreign antigen are crucial
processes for eliciting an effective adaptive host response to the majority of pathogens. The …
processes for eliciting an effective adaptive host response to the majority of pathogens. The …
Chaperone-mediated autophagy: roles in disease and aging
This review focuses on chaperone-mediated autophagy (CMA), one of the proteolytic
systems that contributes to degradation of intracellular proteins in lysosomes. CMA substrate …
systems that contributes to degradation of intracellular proteins in lysosomes. CMA substrate …
Chaperone-mediated autophagy: a unique way to enter the lysosome world
All cellular proteins undergo continuous synthesis and degradation. This permanent
renewal is necessary to maintain a functional proteome and to allow rapid changes in levels …
renewal is necessary to maintain a functional proteome and to allow rapid changes in levels …
Regulation of mammalian autophagy in physiology and pathophysiology
(Macro) autophagy is a bulk degradation process that mediates the clearance of long-lived
proteins and organelles. Autophagy is initiated by double-membraned structures, which …
proteins and organelles. Autophagy is initiated by double-membraned structures, which …
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function
Lysosomes are the primary catabolic compartments of eukaryotic cells. They degrade
extracellular material that has been internalized by endocytosis and intracellular …
extracellular material that has been internalized by endocytosis and intracellular …
A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation
Many annotated long noncoding RNAs (lncRNAs) harbor predicted short open reading
frames (sORFs), but the coding capacities of these sORFs and the functions of the resulting …
frames (sORFs), but the coding capacities of these sORFs and the functions of the resulting …