Agnostic approvals in oncology: getting the right drug to the right patient with the right genomics

V Tateo, PV Marchese, V Mollica, F Massari… - Pharmaceuticals, 2023 - mdpi.com
(1) Background: The oncology field has drastically changed with the advent of precision
medicine, led by the discovery of druggable genes or immune targets assessed through next …

Recent advances in drug delivery and targeting for the treatment of pancreatic cancer

N Pramanik, A Gupta, Y Ghanwatkar… - Journal of Controlled …, 2024 - Elsevier
Despite significant treatment efforts, pancreatic ductal adenocarcinoma (PDAC), the
deadliest solid tumor, is still incurable in the preclinical stages due to multifacet stroma …

Antibacterial potential of trihydroxycyclohexa-2, 4-diene-1-carboxylic acid: Insight from DFT, molecular docking, and molecular dynamic simulation

AE Owen, CM Chima, I Ahmad, W Emori… - Polycyclic Aromatic …, 2024 - Taylor & Francis
Abstract In this study,(z)-5-((3-(2, 3-dihydroxyphenyl) acryloyl) oxy)-1, 3, 4-
trihydroxycyclohexa-2, 4-diene-1-carboxylic acid (chlorogenic acid) was isolated and …

[HTML][HTML] Comprehensive review on endoscopic ultrasound-guided tissue acquisition techniques for solid pancreatic tumor

S Masuda, K Koizumi, K Shionoya… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma is speculated to become the second leading cause of
cancer-related mortality by 2030, a high mortality rate considering the number of cases …

Complete response to alectinib in ALK-fusion metastatic salivary ductal carcinoma

JJ Adashek, S Sapkota, R de Castro Luna… - npj Precision …, 2023 - nature.com
The advent of next-generation sequencing (NGS) has allowed for the identification of novel
therapeutic targets for patients with uncommon cancers. It is well known that fusion …

Understanding the Genetic Landscape of Pancreatic Ductal Adenocarcinoma to Support Personalized Medicine: A Systematic Review

A Pantaleo, G Forte, C Fasano, M Lepore Signorile… - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with
high mortality. Most patients present with an advanced stage of the disease, highlighting the …

[HTML][HTML] Multimodal machine learning models identify chemotherapy drugs with prospective clinical efficacy in dogs with relapsed B-cell lymphoma

AJ Callegari, J Tsang, S Park, D Swartzfager… - Frontiers in …, 2024 - frontiersin.org
Dogs with B-cell lymphoma typically respond well to first-line CHOP-based chemotherapy,
but there is no standard of care for relapsed patients. To help veterinary oncologists select …

Exosomes: Emerging Modulators of Pancreatic Cancer Drug Resistance

M Di Donato, N Medici, A Migliaccio, G Castoria… - Cancers, 2023 - mdpi.com
Simple Summary The high mortality of pancreatic cancer (PaC) is due to different reasons: a
lack of specific symptoms, an unlikely diagnosis, therapies' paucity, and drug resistance …

Exploring the Potential of Compounds Isolated from Laranthus micranthus for the Treatment of Benign Prostatic Hyperplasia: Comprehensive Studies on …

RU Ukpanukpong, AE Azubuike, EI Agwupuye… - Chemistry Africa, 2024 - Springer
Owing to the significant challenges encountered in the diagnosis, management, and
treatment of benign prostatic hyperplasia (BPH), which have emerged as essential clinical …

Exceptional response to MEK inhibition in a patient with RAF1-mutant myxofibrosarcoma: case report and mechanistic overview

E Özgü, E Aydin, A Adibi, ÜM Tokat, O Tutar… - JCO Precision …, 2023 - ascopubs.org
Exceptional Response to MEK Inhibition in a Patient With RAF1-Mutant Myxofibrosarcoma: Case
Report and Mechanistic Overview | JCO Precision Oncology Skip to main content ASCO …